Evaluation of Corticosteroids in Hemophilia

Abstract

A NUMBER of agents have been shown to increase capillary resistance without producing alterations in the coagulation mechanism.^{1 2 3 4} Corticosteroids, in particular, have been effectively used to control thrombocytopenic bleeding in the absence of an elevation of circulating platelet levels and to shorten prolonged bleeding^{5 6 7 8} and control hemorrhage in persons whose coagulation system is otherwise normal.The present communication reports the results of a controlled study of the use of corticosteroids (prednisone) as an adjunct to plasma replacement therapy in patients with hemophilia undergoing extraction of teeth.Methods and MaterialsFrom January 1, 1955, to January 1, 1960, 16 dental operations . . .