T-cell activation and the balance of antibody isotypes in human lymphatic filariasis
- 28 February 1995
- journal article
- review article
- Published by Elsevier BV in Parasitology Today
- Vol. 11 (2), 50-56
- https://doi.org/10.1016/0169-4758(95)80116-2
Abstract
Human filarial infection presents a spectrum of clinical states with two major poles: asymptomatic microfilaraemia and amicrofilaraemic chronic disease. Microfilaremia is associated with a Th1-type tolerance, and maximal IgG4 antibodies, while elephantiasis patients react across a broad range of immune parameters. In this review, Rick Maizels and his colleagues discuss recent advances in the immunology of human filariasis and present a summary of their latest studies in an endemic area of Indonesia.Keywords
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