Genistein, a soy isoflavone, is a potent α‐glucosidase inhibitor
- 10 July 2001
- journal article
- Published by Wiley in FEBS Letters
- Vol. 501 (1), 84-86
- https://doi.org/10.1016/s0014-5793(01)02631-x
Abstract
Genistein is an isoflavone that is known to be contained in soybean. It was proved that genistein plays a pivotal role in homeostasis in the human body. In the course of screening for useful α-glucosidase inhibitors, we isolated and identified genistein as a candidate for α-glucosidase inhibitor from fermentation broths of a Streptomyces sp. Genistein was shown to be a reversible, slow-binding, non-competitive inhibitor of yeast α-glucosidase with a K i value of 5.7×10 −8 M when the enzyme mixture was pretreated with genistein. These results show a possibility that genistein could be a useful tool for metabolic disorders.Keywords
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