Pulmonary Function and Exercise-associated Changes with Chronic Low-Level Paraquat Exposure
- 1 October 2004
- journal article
- Published by American Thoracic Society in American Journal of Respiratory and Critical Care Medicine
- Vol. 170 (7), 773-779
- https://doi.org/10.1164/rccm.200403-266oc
Abstract
The present study was undertaken to test the hypothesis that chronic, low-level paraquat exposure causes restrictive lung function with gas transfer impairment. Three hundred thirty-eight Costa Rican farm workers from banana, coffee, and palm oil farms completed a questionnaire, spirometry, and a test of single-breath carbon monoxide diffusing capacity. Subjects 40 years of age or older, without other medical risk factors, completed maximal cardiopulmonary exercise tests. Most (66.6%) were paraquat handlers; 24.8% of handlers and 27.3% of nonhandlers reported current cigarette smoking. In linear regression models, cumulative paraquat exposure was not an independent predictor of VA, carbon monoxide diffusing capacity, peak oxygen uptake, FVC, or oxygen pulse peak. However, the ventilatory equivalent for CO(2), although within normal range, was significantly higher with increased cumulative paraquat exposure. Oxygen desaturation greater than 5% from rest to peak exercise had an odds ratio of 1.7 (95% confidence interval = 0.9-3.0) with the cumulative paraquat exposure index in models adjusted for age, weight, and smoking status. The association of paraquat exposure with ventilatory equivalent and oxygen desaturation suggests that paraquat may be associated with subclinical gas exchange abnormalities, but overall these findings are consistent with no clinically significant increases in interstitial thickening or restrictive lung disease among this population.Keywords
This publication has 28 references indexed in Scilit:
- Unintentional fatal paraquat poisonings among agricultural workers in Costa Rica: Report of 15 casesAmerican Journal of Industrial Medicine, 1997
- Pesticide poisonings in Costa Rica.Scandinavian Journal of Work, Environment & Health, 1993
- Paraquat Poisoning in Southern Mexico: A Report of 25 CasesArchives of environmental health, 1993
- Paraquat poisoning: findings on chest radiography and CT in 42 patients.American Journal of Roentgenology, 1991
- Paraquat PoisoningDrug Safety, 1990
- The Epidemiology and Prevention of Paraquat PoisoningHuman Toxicology, 1987
- A study of the health of Malaysian plantation workers with particular reference to paraquat spraymen.Occupational and Environmental Medicine, 1981
- The pathology of the lung in paraquat poisoningJournal of Clinical Pathology, 1975
- Fatal Pulmonary Intra-Alveolar Fibrosis after Paraquat IngestionNew England Journal of Medicine, 1974
- Nail damage in spray operators exposed to paraquatOccupational and Environmental Medicine, 1971