Prognostic value of left ventricular mass and geometry in systemic hypertension with left ventricular hypertrophy
- 15 July 1996
- journal article
- Published by Elsevier BV in The American Journal of Cardiology
- Vol. 78 (2), 197-202
- https://doi.org/10.1016/s0002-9149(96)90395-1
Abstract
To determine the independent prognostic significance of left ventricular (LV) mass and geometry (concentric vs eccentric pattern) in hypertensive subjects with LV hypertrophy at echocardiography, 274 subjects were followed for up to 8.7 years (mean 3.2). All patients had systemic hypertension and LV mass ≥125 g/body surface area (BSA) and underwent ambulatory blood pressure (BP) monitoring and echocardiography before treatment. Eccentric and concentric hypertrophy were defined by the ratio between LV posterior wall thickness and LV radius at telediastole 60 and LV mass above median (145 g/BSA) were significant adverse prognostic predictors, while LV geometry (eccentric vs concentric hypertrophy) and ambulatory BP were not. The event rates per 100 patient-years were 1.38 and 3.98, respectively, in the patients with LV mass below and above median (age-adjusted relative risk 2.70; 95% confidence interval [CI] 1.03 to 6.63; p=0.015). In hypertensive subjects with established LV hypertrophy, LV mass, but not its geometric pattern, provides important prognostic information independent of conventional risk markers including office and ambulatory BP.Keywords
This publication has 25 references indexed in Scilit:
- Ambulatory blood pressure. An independent predictor of prognosis in essential hypertension.Hypertension, 1994
- A new method for indexing left ventricular mass for differences in body sizeThe American Journal of Cardiology, 1994
- Asymmetric left ventricular remodeling due to isolated septal thickening in patients with systemic hypertension and normal left ventricular massesThe American Journal of Cardiology, 1994
- Comparison of classification of the severity of hypertension by blood pressure level and by World Health Organization criteria in the prediction of concurrent cardiac abnormalities and subsequent complications in essential hypertensionJournal Of Hypertension, 1993
- Blunted nocturnal fall in blood pressure in hypertensive women with future cardiovascular morbid events.Circulation, 1993
- Left ventricular mass and body size in normotensive children and adults: Assessment of allometric relations and impact of overweightJournal of the American College of Cardiology, 1992
- Patterns of left ventricular hypertrophy and geometric remodeling in essential hypertensionJournal of the American College of Cardiology, 1992
- Relation of Left Ventricular Mass and Geometry to Morbidity and Mortality in Uncomplicated Essential HypertensionAnnals of Internal Medicine, 1991
- Prognostic Implications of Echocardiographically Determined Left Ventricular Mass in the Framingham Heart StudyNew England Journal of Medicine, 1990
- Echocardiographic assessment of left ventricular hypertrophy: Comparison to necropsy findingsThe American Journal of Cardiology, 1986