The Levels of SARS-CoV-2 Specific Antibodies in Human Milk Following Vaccination
- 27 June 2021
- journal article
- research article
- Published by SAGE Publications in Journal of Human Lactation
- Vol. 37 (3), 477-484
- https://doi.org/10.1177/08903344211027112
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines are being administered around the world; however, lactating women were excluded from SARS-CoV-2 vaccine trials. Therefore, knowledge about the effect of vaccination in this specific group is limited. This information is essential to empower lactating women to make a well-informed decision on their choice for vaccination. After natural infection, SARS-CoV-2 specific antibodies are present in human milk, which might offer protection for her newborn. The dynamics of these antibodies in human milk following vaccination remain to be elucidated. To determine the effect of vaccination with BNT162b2 on the levels of SARS-CoV-2 specific IgA in human milk. In this prospective longitudinal study, we included lactating women who received the BNT162b2 vaccine. Human milk samples were collected prior to vaccination and 3, 5, 7, 9, 11, 13, and 15 days after both vaccine doses. Samples were analyzed using enzyme-linked immunosorbent assay against the spike protein of SARS-CoV-2. In total, 366 human milk samples from 26 lactating women were analyzed. A biphasic response was observed, with SARS-CoV-2 specific immunoglobulin A (IgA) starting to increase between day 5 and 7 after the first dose of the vaccine. After the second dose, an accelerated IgA antibody response was observed. After vaccination with the mRNA-based BNT162b2 vaccine, a SARS-CoV-2 specific antibody response was observed in human milk. The presence of SARS-CoV-2 specific IgA after vaccination is important as antibodies are transferred via human milk, and thereby might provide protection to infants against COVID-19.Keywords
Funding Information
- Stichting Steun Emmakinderziekenhuis
This publication has 19 references indexed in Scilit:
- Robust and Specific Secretory IgA Against SARS-CoV-2 Detected in Human MilkiScience, 2020
- SARS-CoV-2 immunity: review and applications to phase 3 vaccine candidatesThe Lancet, 2020
- COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responsesNature, 2020
- Hospitalization Rates and Characteristics of Children Aged <18 Years Hospitalized with Laboratory-Confirmed COVID-19 — COVID-NET, 14 States, March 1–July 25, 2020Morbidity and Mortality Weekly Report (MMWR), 2020
- Maternal Immunization: Nature Meets NurtureFrontiers in Microbiology, 2020
- Psychological stress reduces the immunological benefits of breast milkStress & Health, 2019
- Breastfeeding Rates and Programs in EuropeJournal of Pediatric Gastroenterology and Nutrition, 2019
- Breastfeeding for reducing the risk of pneumonia morbidity and mortality in children under two: a systematic literature review and meta-analysisBMC Public Health, 2013
- IgA and Neutralizing Antibodies to Influenza A Virus in Human Milk: A Randomized Trial of Antenatal Influenza ImmunizationPLOS ONE, 2013
- Salmon Consumption during Pregnancy Alters Fatty Acid Composition and Secretory IgA Concentration in Human Breast MilkJournal of Nutrition, 2012