Replicative Senescence: the Human Fibroblast Comes of Age
- 7 September 1990
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 249 (4973), 1129-1133
- https://doi.org/10.1126/science.2204114
Abstract
Human diploid fibroblasts undergo replicative senescence predominantly because of arrest at the G1/S boundary of the cell cycle. Senescent arrest resembles a process of terminal differentiation that appears to involve repression of proliferation-promoting genes with reciprocal new expression of antiproliferative genes, although post-transcriptional factors may also be involved. Identification of participating genes and clarification of their mechanisms of action will help to elucidate the universal cellular decline of biological aging and an important obverse manifestation, the rare escape of cells from senescence leading to immortalization and oncogenesis.This publication has 70 references indexed in Scilit:
- Telomeres shorten during ageing of human fibroblastsNature, 1990
- Weight change, survival time and cause of death in Dutch elderlyArchives of Gerontology and Geriatrics, 1990
- Novel monoclonal antibodies identify antigenic determinants unique to cellular senescenceJournal of Cellular Physiology, 1990
- Identification of a highly abundant cDNA isolated from senescent WI-38 cellsExperimental Cell Research, 1989
- Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiationCell, 1989
- The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory elementCell, 1989
- Existence of High Abundance Antiproliferative mRNA's in Senescent Human Diploid FibroblastsScience, 1986
- Aging in vitro: Growth of cultured cells from the Galapagos tortoiseExperimental Cell Research, 1974
- Ultraviolet-Induced Repair Replication in Aging Diploid Human Cells (WI-38)Radiation Research, 1973
- Doubling potential, calendar time, and senescence of human diploid cells in cultureExperimental Cell Research, 1973