A Protein That Binds to a cis-acting Element of Wheat Histone Genes Has a Leucine Zipper Motif
- 1 September 1989
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 245 (4921), 965-967
- https://doi.org/10.1126/science.2772648
Abstract
The structure and function of transcription factors of higher plants was studied by isolating cDNA clones encoding a wheat sequence-specific DNA binding protein. A hexameric nucleotide motif, ACGTCA, is located upstream from the TATA box of several plant histone genes. It has been suggested that this motif is essential for efficient transcription of the wheat histone H3 gene. A wheat nuclear protein, HBP-1 (histone DNA binding protein-1), which specifically binds to the hexameric motif, has previously been identified as a putative transcription factor. A cDNA clone encoding HBP-1 has been isolated on the basis of specific binding of HBP-1 to the hexameric motif. The deduced amino acid sequence indicates that HBP-1 contains the leucine zipper motif, which represents a characteristic property of several eukaryotic transcription factors.This publication has 25 references indexed in Scilit:
- Cyclic AMP-Responsive DNA-Binding Protein: Structure Based on a Cloned Placental cDNAScience, 1988
- The pituitary-specific transcription factor GHF-1 is a homeobox-containing proteinCell, 1988
- A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotypeCell, 1988
- How eukaryotic transcriptional activators workNature, 1988
- Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elementsCell, 1988
- Isolation of the gene encoding the S. cerevisiae heat shock transcription factorCell, 1988
- Cloning of a Lymphoid-Specific cDNA Encoding a Protein Binding the Regulatory Octamer DNA MotifScience, 1988
- In situ detection of sequence-specific DNA binding activity specified by a recombinant bacteriophage.Genes & Development, 1988
- Molecular cloning of an enhancer binding protein:Isolation by screening of an expression library with a recognition site DNACell, 1988
- Nuclear protein(s) binding to the conserved DNA hexameric sequence postulated to regulate transcription of wheat histone genesFEBS Letters, 1987