Injectable calcium phosphate cement: Effects of powder‐to‐liquid ratio and needle size
- 16 July 2007
- journal article
- research article
- Published by Wiley in Journal of Biomedical Materials Research Part B: Applied Biomaterials
- Vol. 84B (2), 493-502
- https://doi.org/10.1002/jbm.b.30896
Abstract
Calcium phosphate cement (CPC) sets in situ and forms apatite with excellent osteoconductivity and bone‐replacement capability. The objectives of this study were to formulate an injectable tetracalcium phosphate‐dicalcium phosphate cement (CPCD), and investigate the powder/liquid ratio and needle‐size effects. The injection force (mean ± SD; n = 4) to extrude the paste increased from (8 ± 2) N using a 10‐gauge needle to (144 ± 17) N using a 21‐gauge needle (p < 0.05). With the 10‐gauge needle, the mass percentage of extruded paste was (95 ± 4)% at a powder/liquid ratio of 3; it decreased to (70 ± 12)% at powder/liquid = 3.5 (p < 0.05). A relationship was established between injection force, F, and needle lumen cross‐sectional area, A: F = 5.0 + 38.7/A0.8. Flexural strength, S, (mean ± SD; n = 5) increased from (5.3 ± 0.8) MPa at powder/liquid= 2 to (11.0 ± 0.8) MPa at powder/liquid = 3.5 (p < 0.05). Pore volume fraction, P, ranged from 62.4% to 47.9%. A relationship was established: S = 47.7 × (1 – P)2.3. The strength of the injectable CPCD matched/exceeded the reported strengths of sintered porous hydroxyapatite implants that required machining. The novel injectable CPCD with a relatively high strength may be useful in filling defects with limited accessibility such as periodontal repair and tooth root‐canal fillings, and in minimally‐invasive techniques such as percutaneous vertebroplasty to fill the lesions and to strengthen the osteoporotic bone. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2008Keywords
This publication has 45 references indexed in Scilit:
- Injectable and macroporous calcium phosphate cement scaffoldBiomaterials, 2006
- Formation of hydroxyapatite–polyphosphazene polymer composites at physiologic temperatureJournal of Biomedical Materials Research Part A, 2006
- Injectable and rapid‐setting calcium phosphate bone cement with dicalcium phosphate dihydrateJournal of Biomedical Materials Research Part B: Applied Biomaterials, 2005
- Fast setting calcium phosphate–chitosan scaffold: mechanical properties and biocompatibilityBiomaterials, 2004
- Calcium phosphate sol–gel-derived thin films on porous-surfaced implants for enhanced osteoconductivity. Part I: Synthesis and characterizationBiomaterials, 2004
- Effects of Spherical Tetracalcium Phosphate on Injectability and Basic Properties of Apatitic CementKey Engineering Materials, 2003
- Kinetic study of citric acid influence on calcium phosphate bone cements as water‐reducing agentJournal of Biomedical Materials Research, 2002
- Osteoblast behaviour on HA/PE composite surfaces with different HA volumesBiomaterials, 2002
- Tissue Engineering: Orthopedic ApplicationsAnnual Review of Biomedical Engineering, 1999
- The worldwide problem of osteoporosis: Insights afforded by epidemiologyBone, 1995