The Second-Derivative Spectrophotometric Assay of a Multicomponent Analgetic Mixture
- 1 March 2000
- journal article
- research article
- Published by Taylor & Francis Ltd in Spectroscopy Letters
- Vol. 33 (2), 173-183
- https://doi.org/10.1080/00387010009350067
Abstract
In this paper the second-derivative spectrophotometric method for the simultaneous determination of some analgetic ingredients was described. Optimal conditions for the quantitative analysis of the three-component analgetic mixture of Dalivon® tablets were settled. The second-derivative order of the spectra in sodium hydroxide with the wavelength modulation was used. For the determination of paracetamol the “zero-crossing” technique was applied, but for propyphenazone and caffeine the characteristic peak amplitude had to be corrected. The authors propose this second-derivative spectrophotometry for a rapid, simple, precise and accurate determination of the Dalivon® tablets or a corresponding multicomponent mixture.This publication has 18 references indexed in Scilit:
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