Can We Use Biomarkers and Functional Assays to Implement Personalized Therapies in Transplantation?
- 15 June 2009
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Transplantation
- Vol. 87 (11), 1595-1601
- https://doi.org/10.1097/tp.0b013e3181a6b2cf
Abstract
Research in transplantation focuses on minimizing immunosuppression to decrease side effects and costs. Indeed, in some patients, partial or complete cessation of immunosuppression is successful, but currently we have no means of identifying suitable patients a priori. Current withdrawal protocols, which do not implement surrogate markers, carry a significant risk of graft injury. To minimize the risk, immune monitoring strategies are required. Here, we review recently described biomarkers and assays, which might enable identification of patients suitable for partial or complete weaning and patients at risk of rejection. The predictive power of these parameters has to be tested in prospective multicenter trials.This publication has 60 references indexed in Scilit:
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