The hsc70 gene which is slightly induced by heat is the main virus inducible member of the hsp70 gene family
- 5 December 1994
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 355 (3), 282-286
- https://doi.org/10.1016/0014-5793(94)01210-5
Abstract
We have found that SV40 infection of CV1 cells induces the synthesis of a 72 kDa protein that upon molecular cloning was shown to be the product of the hsc70 gene. The above gene product was found to be mainly virus inducible, in contrast to the hsp70 gene product which was mainly heat inducible. The two genes were found to be cell cycle regulated in a distinctively different manner.Keywords
This publication has 18 references indexed in Scilit:
- THE HEAT-SHOCK PROTEINSAnnual Review of Genetics, 1988
- Specific inhibition of simian virus 40 protein synthesis by heat and arsenite treatmentEuropean Journal of Biochemistry, 1988
- λ ZAP: a bacteriophage λ expression vector within vivoexcision propertiesNucleic Acids Research, 1988
- Structure and expression of a human gene coding for a 71 kd heat shock ‘cognate’ proteinNucleic Acids Research, 1987
- Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extractionAnalytical Biochemistry, 1987
- Expression of human HSP70 during the synthetic phase of the cell cycle.Proceedings of the National Academy of Sciences of the United States of America, 1986
- Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70.Proceedings of the National Academy of Sciences of the United States of America, 1985
- Induction of the synthesis of a 70,000 dalton mammalian heat shock protein by the adenovirus E1A gene productCell, 1982
- SV40-transformed simian cells support the replication of early SV40 mutantsCell, 1981
- Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase IJournal of Molecular Biology, 1977