Calorie restriction and the exercise of chromatin
- 16 July 2009
- journal article
- review article
- Published by Cold Spring Harbor Laboratory in Genes & Development
- Vol. 23 (16), 1849-1869
- https://doi.org/10.1101/gad.1807009
Abstract
Since the earliest stages of evolution, organisms have faced the challenge of sensing and adapting to environmental changes for their survival under compromising conditions such as food depletion or stress. Implicit in these responses are mechanisms developed during evolution that include the targeting of chromatin to allow or prevent expression of fundamental genes and to protect genome integrity. Among the different approaches to study these mechanisms, the analysis of the response to a moderate reduction of energy intake, also known as calorie restriction (CR), has become one of the best sources of information regarding the factors and pathways involved in metabolic adaptation from lower to higher eukaryotes. Furthermore, responses to CR are involved in life span regulation—conserved from yeast to mammals—and therefore have garnered major research interest. Herein we review current knowledge of responses to CR at the molecular level and their functional link to chromatin.Keywords
This publication has 178 references indexed in Scilit:
- SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life SpanCell, 2009
- SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during AgingCell, 2008
- SirT1 Gain of Function Increases Energy Efficiency and Prevents Diabetes in MiceCell Metabolism, 2008
- Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant MiceCancer Cell, 2008
- The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian ControlCell, 2008
- SIRT1 Regulates Circadian Clock Gene Expression through PER2 DeacetylationCell, 2008
- Transcriptional control by PARP-1: chromatin modulation, enhancer-binding, coregulation, and insulationCurrent Opinion in Cell Biology, 2008
- Mitochondria—A Nexus for Aging, Calorie Restriction, and Sirtuins?Cell, 2008
- Ruminations on dietary restriction and agingCellular and Molecular Life Sciences, 2007
- The PARP superfamilyBioEssays, 2004