The Serum Amino Acid Spectrum of Insulin-Dependent Diabetics and Controls from Ethiopia
- 1 August 1988
- journal article
- research article
- Published by Georg Thieme Verlag KG in Experimental and Clinical Endocrinology & Diabetes
- Vol. 91 (03), 271-276
- https://doi.org/10.1055/s-0029-1210758
Abstract
The serum amino acid spectrum was examined in healthy men and insulin-dependent diabetics from Ethiopia. Comparison of serum amino acids of controls from Gondar with Ethiopians after adaptation to a free European diet revealed a marginal low protein nutrition, but not the characteristic changes of malnutrition or experimental starvation. There was no apparent nutritional deficiency of sulphur-containing amino acids in Ethiopians. Insulin-dependent diabetics showed significantly elevated serum levels of BCAA indicating an accelerated protein catabolism in recent-onset insulin-deficient patients and known diabetics respectively, most of them in poor metabolic condition. Serum glutamine levels were reduced, suggesting a considerable renal contribution to the hyperglycaemia/glucosuria of diabetics. The data may be best explained by the low residual insulin secretion at diabetes onset or by the poor degree of metabolic control of known Ethiopian diabetics.Keywords
This publication has 8 references indexed in Scilit:
- Ketosis, Serum Carnitine and its Precursor Amino Acids in Normal and Diabetic EthiopiansExperimental and Clinical Endocrinology & Diabetes, 1987
- Impaired phenylalanine-tyrosine conversion in patients with iron-deficiency anemia studied by a L-(2H5)phenylalanine-loading testThe American Journal of Clinical Nutrition, 1986
- The effect of metabolic control on leucine metabolism in Type 1 (insulin-dependent) diabetic patientsDiabetologia, 1986
- The Frequency of Islet Cell Surface Antibodies in Newly Diagnosed Diabetics from Ethiopia1)Experimental and Clinical Endocrinology & Diabetes, 1986
- Interorgan metabolism of amino acids in streptozotocin-diabetic ketoacidotic ratAmerican Journal of Physiology-Endocrinology and Metabolism, 1983
- Branched-chain amino acids and alanine as indices of the metabolic control in Type 1 (insulin-dependent) and Type 2 (non-insulin-dependent) diabetic patientsDiabetologia, 1982
- Arteriovenous differences for amino acids and lactate across kidneys of normal and acidotic ratsBiochemical Journal, 1976
- The significance and mechanism of an increased serum phenylalanine-tyrosine ratio during infectionThe American Journal of Clinical Nutrition, 1976