Subcapsular Hematoma After Laparoscopic Cholecystectomy, Associated With Ketorolac Administration
- 10 September 1994
- journal article
- case report
- Published by Wiley in Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
- Vol. 14 (5), 613-615
- https://doi.org/10.1002/j.1875-9114.1994.tb02859.x
Abstract
Ketorolac is the first injectable nonsteroidal antiinflammatory drug used as an analgesic in the perioperative period. Its adverse effect profile is different from that of the opioid analgesics; in particular, in its lack of respiratory depressive actions. However, ketorolac has risks associated with its perioperative administration, including episodes of substantial gastrointestinal bleeding. A patient undergoing elective laparoscopic cholecystectomy developed a subcapsular hepatic hematoma shortly after receiving a dose of injectable ketorolac. No evidence of parenchymal injury was found on laparoscopy, which argues against iatrogenic trauma. Clinicians should be aware that ketorolac may cause or aggravate bleeding, and it should be used with caution in perioperative patients.This publication has 12 references indexed in Scilit:
- The use of intravenous ketorolac for the treatment of renal colic in the emergency departmentThe American Journal of Emergency Medicine, 1993
- Anaphylactoid Reaction following Ketorolac Tromethamine AdministrationAnnals of Pharmacotherapy, 1992
- Acute Renal Failure in an Elderly Woman following Intramuscular Ketorolac AdministrationAnnals of Pharmacotherapy, 1992
- Ketorolac for sickle cell vaso-occlusive crisis pain in the emergency department: lack of a narcotic-sparing effectAnnals of Emergency Medicine, 1992
- Effects on Biliary Tract Pressure in Humans of Intravenous Ketorolac Tromethamine Compared With Morphine and PlaceboAnesthesia & Analgesia, 1992
- Massive Gastrointestinal Bleeding Associated With Ketorolac AdministrationJournal of Pharmacy Practice, 1992
- Upper gastrointestinal bleeding in relation to previous use of analgesics and non-steroidal anti-inflammatory drugsThe Lancet, 1991
- KetorolacDrugs, 1990
- Haemostatic Effects of Ketorolac with and without Concomitant Heparin in Normal VolunteersThrombosis and Haemostasis, 1988
- Endoscopic Studies of Gastric and Duodenal Injury after the Use of Ibuprofen, Aspirin, and Other Nonsteroidal Anti-Inflammatory AgentsAmerican Journal Of Medicine, 1984