The circadian clock system in the mammalian retina
- 5 June 2008
- Vol. 30 (7), 624-633
- https://doi.org/10.1002/bies.20777
Abstract
Daily rhythms are a ubiquitous feature of living systems. Generally, these rhythms are not just passive consequences of cyclic fluctuations in the environment, but instead originate within the organism. In mammals, including humans, the master pacemaker controlling 24‐hour rhythms is localized in the suprachiasmatic nuclei of the hypothalamus. This circadian clock is responsible for the temporal organization of a wide variety of functions, ranging from sleep and food intake, to physiological measures such as body temperature, heart rate and hormone release. The retinal circadian clock was the first extra‐SCN circadian oscillator to be discovered in mammals and several studies have now demonstrated that many of the physiological, cellular and molecular rhythms that are present within the retina are under the control of a retinal circadian clock, or more likely a network of hierarchically organized circadian clocks that are present within this tissue. BioEssays 30:624–633, 2008.Keywords
This publication has 113 references indexed in Scilit:
- Intrinsic Circadian Clock of the Mammalian Retina: Importance for Retinal Processing of Visual InformationCell, 2007
- Clock gene expression in the rat retina: Effects of lighting conditions and photoreceptor degenerationBrain Research, 2007
- Localization of a circadian clock in mammalian photoreceptorsThe FASEB Journal, 2007
- Effect of photoreceptor degeneration on circadian photoreception and free-running period in the Royal College of Surgeons ratBrain Research, 2007
- Comparison of clock gene expression in SCN, retina, heart, and liver of miceBiochemical and Biophysical Research Communications, 2006
- Molecular components of the mammalian circadian clockHuman Molecular Genetics, 2006
- Temporal coupling of cyclic AMP and Ca2+/calmodulin‐stimulated adenylyl cyclase to the circadian clock in chick retinal photoreceptor cellsJournal of Neurochemistry, 2006
- Circadian organization of the mammalian retinaProceedings of the National Academy of Sciences of the United States of America, 2006
- Signaling mediated by the dopamine D2 receptor potentiates circadian regulation by CLOCK:BMAL1Proceedings of the National Academy of Sciences of the United States of America, 2006
- Role of the CLOCK Protein in the Mammalian Circadian MechanismScience, 1998