Embryo Effects in Human Implantation
- 1 September 2001
- journal article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 943 (1), 1-16
- https://doi.org/10.1111/j.1749-6632.2001.tb03785.x
Abstract
Embryonic implantation requires coordinated development of the blastocyst and the maternal endometrium. Considerable advances have been made in the understanding of the cell biology of human embryo and maternal endometrium as separate entities. Nevertheless, communication between them and their reciprocal effects on each other constitute an exciting and as-yet unsolved problem in reproductive medicine. Cross-talk among the embryo, endometrium, and the corpus luteum are known to occur in ruminants and primates; more specifically, endometrial-embryonic interactions have been reported in rodents and primates. Here, we present updated information in humans on the embryonic regulation of endometrial epithelial molecules such as chemokines, adhesion molecules, antiadhesion molecules, and leptin during the apposition and adhesion phases of human implantation. Also the embryonic induction of apoptosis in endometrial epithelial cells as a mechanism for crossing the epithelial barrier will be described.Keywords
This publication has 82 references indexed in Scilit:
- Expression of Ob Receptor in Normal Human Adrenals: Differential Regulation of Adrenocortical and Adrenomedullary Function by LeptinJournal of Clinical Endocrinology & Metabolism, 1998
- Cre-loxP–mediated Inactivation of the α6A Integrin Splice Variant In Vivo: Evidence for a Specific Functional Role of α6A in Lymphocyte Migration but Not in Heart DevelopmentThe Journal of cell biology, 1998
- Decreased Leptin Levels in Normal Weight Women with Hypothalamic Amenorrhea: The Effects of Body Composition and Nutritional IntakeJournal of Clinical Endocrinology & Metabolism, 1998
- ICAMs Redistributed by Chemokines to Cellular Uropods as a Mechanism for Recruitment of T LymphocytesThe Journal of cell biology, 1997
- The OB Protein (Leptin) Pathway - A Link Between Adipose Tissue Mass and Central Neural NetworksHormone and Metabolic Research, 1996
- Ovarian steroid hormones regulate granulocyte-macrophage colony- stimulating factor synthesis by uterine epithelial cells in the mouseBiology of Reproduction, 1996
- Involvement of programmed cell death in preimplantation embryo demiseHuman Reproduction Update, 1995
- CC chemokines in allergic inflammationImmunology Today, 1994
- Integrins: Versatility, modulation, and signaling in cell adhesionCell, 1992
- Human monocyte chemoattractant protein‐1 (MCP‐1) Full‐length cDNA cloning, expression in mitogen‐stimulated blood mononuclear leukocytes, and sequence similarity to mouse competence gene JEFEBS Letters, 1989