Calcium Channels Formed by Mammalian Trp Homologues.

Abstract

Homologues of Drosophila trp genes have been isolated from mammalian species in hope that they may constitute the molecular basis of capacitative Ca²⁺ entry. Expression of Trps suggests that they form Ca²⁺ influx channels regulated by either store depletion or a more upstream event. Store-operated Trp channels can be formed by heteromultimerization.