In vivo activity of mutacin B-Ny266
Open Access
- 9 September 2005
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 56 (5), 869-871
- https://doi.org/10.1093/jac/dki295
Abstract
Objectives: The objective of this study was to assess the in vivo activity of mutacin B-Ny266 (a bacteriocin produced by Streptococcus mutans) in order to eventually use it as an antibiotic. Methods: Intraperitoneal infection was induced with a methicillin-susceptible Staphylococcus aureus strain in mice. Some of the mice were simultaneously injected intraperitoneally with mutacin B-Ny266, some with the vehicle only and some with vancomycin. Results: While there was 70 and 100% mortality in the control groups of mice, no mortality was observed in the mice injected with vancomycin or mutacin B-Ny266. Conclusions: The results presented here show, for the first time, the in vivo efficacy of a mutacin (B-Ny266) against an experimental intraperitoneal infection by S. aureus in a mouse model.Keywords
This publication has 19 references indexed in Scilit:
- Challenges in Antimicrobial Drug Discovery and the Potential of Nucleoside AntibioticsCurrent Medicinal Chemistry, 2004
- Recent developments in antibiotic treatmentInfectious Disease Clinics of North America, 2003
- Ribosomally synthesized peptides with antimicrobial properties: biosynthesis, structure, function, and applicationsBiotechnology Advances, 2003
- Mechanisms of Antimicrobial Peptide Action and ResistancePharmacological Reviews, 2003
- The future for antibiotics: Bacterial membrane disintegratorsDrugs of the Future, 2003
- Development of novel antibacterial peptides that kill resistant isolatesPeptides, 2002
- National Nosocomial Infections Surveillance (NNIS) System Report, Data Summary from January 1992-June 2001, Issued August 2001American Journal of Infection Control, 2001
- Comparison of the activity spectra against pathogens of bacterial strains producing a mutacin or a lantibioticCanadian Journal of Microbiology, 2001
- Peptide antibioticsThe Lancet, 1997
- Preliminary grouping of mutacinsCanadian Journal of Microbiology, 1995