Studies on the Base-Promoted Enantioselective Aldol Reaction between an (S,S)-2-OXO-2-Propionyl-1,3,2- Oxazaphosphorinane and Benzaldehyde
- 1 February 1993
- journal article
- Published by Informa UK Limited in Phosphorus, Sulfur, and Silicon and the Related Elements
- Vol. 75 (1-4), 47-50
- https://doi.org/10.1080/10426509308037361
Abstract
The synthesis of an (S,S)-2-oxo-2-propionyl-1,3,2-oxazaphosphorinane, via the condensation of (S)- 1 -N-isopropylbutan-2-ol (3) with methyl dichloro phosphite (CH3OPCl2) followed by the Michaelis-Arbusov condensation reaction with propionyl chloride, will be described. We will also present the results of OUT investigations which describe the nature of the aldol reaction involving the enolate of oxazaphosphorinane 5 with benzaldehyde.Keywords
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