Adjuvant therapies in the management of medication‐related osteonecrosis of the jaws: Systematic review
- 10 September 2019
- journal article
- review article
- Published by Wiley in Head & Neck
- Vol. 41 (12), 4209-4228
- https://doi.org/10.1002/hed.25944
Abstract
Background We investigated the efficacy of hyperbaric oxygen (HBO), low‐intensity laser (LIL), and platelet‐rich plasma (PRP) in the management of medication‐related osteonecrosis of the jaws (MRONJ). Methods A literature search was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses statement. Two examiners independently assessed eligibility and risk of bias and extracted data. Results There was improvement in 75.6% of the 41 patients submitted to HBO, with positive effects on pain relief and decreased size and number of lesions at a faster rate, with better effects when the drug was discontinued. For LIL, 158 (64.2%) of the 246 patients/sites improved the symptoms and 98 (39.8%) healed completely. Fourteen (17.3%) of the 81 patients treated with PRP significantly improved the symptoms and 65 (80.2%) completely healed. Conclusions These therapies served as safe and effective adjuvant modalities for MRONJ treatment. The lack of randomized clinical trials evidences the need for more high‐quality investigations on the subject.Keywords
This publication has 71 references indexed in Scilit:
- Bisphosphonate‐related osteonecrosis of the jaws: analysis of a case series at a dental schoolSpecial Care in Dentistry, 2013
- Use of platelet-rich plasma in the treatment of bisphosphonate-related osteonecrosis of the jawInternational Journal of Oral & Maxillofacial Surgery, 2012
- A Retrospective Study Evaluating Frequency and Risk Factors of Osteonecrosis of the Jaw in 576 Cancer Patients Receiving Intravenous BisphosphonatesAmerican Journal of Clinical Oncology, 2012
- Comparative Evaluation of Antimicrobial Effects of Er:YAG, Diode, and CO2 Lasers on Titanium Discs: An Experimental StudyJournal of Oral and Maxillofacial Surgery, 2012
- Surgical Approach and Laser Applications in BRONJ Osteoporotic and Cancer PatientsJournal of Osteoporosis, 2012
- Early Surgical Laser-Assisted Management of Bisphosphonate-Related Osteonecrosis of the Jaws (BRONJ): A Retrospective Analysis of 101 Treated Sites with Long-Term Follow-UpPhotomedicine and Laser Surgery, 2012
- Bisphosphonate-Related Osteonecrosis of the Jaws–An Initial Case Series Report of Treatment Combining Partial Bone Resection and Autologous Platelet-Rich PlasmaJournal of Oral and Maxillofacial Surgery, 2011
- Bisphosphonate-related osteonecrosis: laser-assisted surgical treatment or conventional surgery?Lasers in Medical Science, 2011
- Risk Factors for Osteonecrosis of the JawsJournal of Dental Research, 2011
- A retrospective study assessing the incidence, risk factors and comorbidities of pamidronate-related necrosis of the jaws in multiple myeloma patientsAnnals of Oncology, 2007