Mitochondria and neuroprotection in stroke: Cationic arginine-rich peptides (CARPs) as a novel class of mitochondria-targeted neuroprotective therapeutics
Open Access
- 13 September 2018
- journal article
- review article
- Published by Elsevier BV in Neurobiology of Disease
- Vol. 121, 17-33
- https://doi.org/10.1016/j.nbd.2018.09.010
Abstract
Stroke is the second leading cause of death globally and represents a major cause of devastating long-term disability. Despite sustained efforts to develop clinically effective neuroprotective therapies, presently there is no clinically available neuroprotective agent for stroke. As a central mediator of neurodamaging events in stroke, mitochondria are recognised as a critical neuroprotective target, and as such, provide a focus for developing mitochondrial-targeted therapeutics. In recent years, cationic arginine-rich peptides (CARPs) have been identified as a novel class of neuroprotective agent with several demonstrated mechanisms of action, including their ability to target mitochondria and exert positive effects on the organelle. This review provides an overview on neuronal mitochondrial dysfunction in ischaemic stroke pathophysiology and highlights the potential beneficial effects of CARPs on mitochondria in the ischaemic brain following stroke.Keywords
Funding Information
- Department of Neurosurgery
- Sir Charles Gairdner Hospital
- Neurotrauma Research Program of Western Australia research grant
- University of Notre Dame Australia
- University Postgraduate Award (UPA)
This publication has 231 references indexed in Scilit:
- Damage to mitochondrial complex I during cardiac ischemia reperfusion injury is reduced indirectly by anti-anginal drug ranolazineBiochimica et Biophysica Acta (BBA) - Bioenergetics, 2012
- Cell Penetrating Peptides in the Delivery of BiopharmaceuticalsBiomolecules, 2012
- Is mPTP the gatekeeper for necrosis, apoptosis, or both?Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2011
- Metabolic and transmitter changes in core and penumbra after middle cerebral artery occlusion in miceBrain Research, 2010
- Arginine-Rich Peptides Destabilize the Plasma Membrane, Consistent with a Pore Formation Translocation Mechanism of Cell-Penetrating PeptidesBiophysical Journal, 2009
- Mitochondrial and apoptotic neuronal death signaling pathways in cerebral ischemiaBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2009
- Proteomic analysis of protein tyrosine nitration after ischemia reperfusion injury: Mitochondria as the major targetBiochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2009
- Mitochondrial calcium function and dysfunction in the central nervous systemBiochimica et Biophysica Acta (BBA) - Bioenergetics, 2009
- The rotary mechanism of the ATP synthaseArchives of Biochemistry and Biophysics, 2008
- 1,026 Experimental treatments in acute strokeAnnals of Neurology, 2006