Cell death by autophagy: facts and apparent artefacts
Top Cited Papers
- 4 November 2011
- journal article
- review article
- Published by Springer Science and Business Media LLC in Cell Death & Differentiation
- Vol. 19 (1), 87-95
- https://doi.org/10.1038/cdd.2011.146
Abstract
Autophagy (the process of self-digestion by a cell through the action of enzymes originating within the lysosome of the same cell) is a catabolic process that is generally used by the cell as a mechanism for quality control and survival under nutrient stress conditions. As autophagy is often induced under conditions of stress that could also lead to cell death, there has been a propagation of the idea that autophagy can act as a cell death mechanism. Although there is growing evidence of cell death by autophagy, this type of cell death, often called autophagic cell death, remains poorly defined and somewhat controversial. Merely the presence of autophagic markers in a cell undergoing death does not necessarily equate to autophagic cell death. Nevertheless, studies involving genetic manipulation of autophagy in physiological settings provide evidence for a direct role of autophagy in specific scenarios. This article endeavours to summarise these physiological studies where autophagy has a clear role in mediating the death process and discusses the potential significance of cell death by autophagy.This publication has 75 references indexed in Scilit:
- Autophagy and apoptosis: what is the connection?Trends in Cell Biology, 2011
- ATG12 Conjugation to ATG3 Regulates Mitochondrial Homeostasis and Cell DeathCell, 2010
- Mammalian autophagy: core molecular machinery and signaling regulationCurrent Opinion in Cell Biology, 2010
- TOR-dependent control of autophagy: biting the hand that feedsCurrent Opinion in Cell Biology, 2010
- Autophagy takes flight in DrosophilaFEBS Letters, 2010
- Autophagy, Not Apoptosis, Is Essential for Midgut Cell Death in DrosophilaCurrent Biology, 2009
- Autophagy in Drosophila melanogasterBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2009
- Warts Is Required for PI3K-Regulated Growth Arrest, Autophagy, and Autophagic Cell Death in DrosophilaCurrent Biology, 2008
- Growth Arrest and Autophagy Are Required for Salivary Gland Cell Degradation in DrosophilaCell, 2007
- Direct Induction of Autophagy by Atg1 Inhibits Cell Growth and Induces Apoptotic Cell DeathCurrent Biology, 2007