Complete remission of relapsing high-grade angiosarcoma with single-agent metronomic trofosfamide
- 1 September 2006
- journal article
- case report
- Published by Ovid Technologies (Wolters Kluwer Health) in Anti-Cancer Drugs
- Vol. 17 (8), 997-998
- https://doi.org/10.1097/01.cad.0000224453.39200.d7
Abstract
A limited repertoire of chemotherapeutics is available for the therapy of metastasizing angiosarcoma. Moreover, response rates are typically low and outcomes are unfavorable. Metronomically, dosed oral chemotherapy provides a convenient treatment option and surprisingly high response rates have been published for small patient groups. We report on a case from our clinic, in which a complete response with oral trofosfamide was achieved in a patient suffering from relapsed high-grade angiosarcoma metastasizing to the liver and lung. The patient experienced minimal side-effects from her trofosfamide treatment. Responses like this are encouraging and should make us rethink treatment approaches for metastasizing soft-tissue sarcoma. The mechanism of action of metronomic chemotherapy, although thought to be antiangiogenic in nature, is still unclear, as is the additive effect of angiogenic inhibitors like cyclooxygenase II inhibitors or peroxisome proliferator-activated receptor-gamma agonists. Prospective studies that include the examination of patient samples during treatment are ongoing in order to optimize further development of this novel therapeutic approach.Keywords
This publication has 7 references indexed in Scilit:
- RETRACTED ARTICLE: New drug developments for patients with metastatic soft tissue sarcomaCurrent Oncology Reports, 2005
- Recent Developments in Salvage Chemotherapy for Patients with Metastatic Soft Tissue SarcomaDrugs, 2005
- Tumor-Associated Endothelial Cells with Cytogenetic AbnormalitiesCancer Research, 2004
- The anti-angiogenic basis of metronomic chemotherapyNature Reviews Cancer, 2004
- Antiangiogenetic therapy with pioglitazone, rofecoxib, and metronomic trofosfamide in patients with advanced malignant vascular tumorsCancer, 2003
- Phase II study of oral trofosfamide as palliative therapy in pretreated patients with metastatic soft-tissue sarcomaAnti-Cancer Drugs, 1999
- Oral trofosfamide: an active drug in the treatment of soft-tissue sarcomaCancer Chemotherapy and Pharmacology, 1995