Placental to Fetal Transfer of Mercury and Fetotoxicity.
Open Access
- 1 January 2002
- journal article
- review article
- Published by Tohoku University Medical Press in The Tohoku Journal of Experimental Medicine
- Vol. 196 (2), 79-88
- https://doi.org/10.1620/tjem.196.79
Abstract
Mercury vapor is known penetrate the placental barrier more easily than inorganic mercury. A relative amount of mercury accumulates in the fetus after exposure of pregnant animals to mercury vapor. Mercury concentration in fetal organs is much lower than that in maternal organs except the liver, and fetal liver shows significantly higher mercury concentrations than maternal liver. In fetal liver, a substantial portion of mercury is bound to metallothionein (MT), which plays an important role as a reservoir of mercury during the prenatal period. The mercury retained in fetal liver is redistributed to other organs, such as the brain and kidney, with diminishing MT levels during postnatal development. Consequently, an increase in mercury concentration in the brain and kidney of the neonate is observed. In studies on animal offspring in utero exposed to mercury vapor, behavioral changes, such as radial arm maze, morris maze and lever-press durations, are observed when the levels of mercury vapor exceed the threshold limit value (TLV).Keywords
This publication has 34 references indexed in Scilit:
- Relationship between Catalase Activity and Uptake of Elemental Mercury by Rat BrainActa Pharmacologica et Toxicologica, 2009
- MERCURY EXPOSURE IN UTERO AND DURING INFANCYJournal of Toxicology and Environmental Health, Part A, 2001
- Percutaneous Absorption of Mercury Vapor by ManArchives of environmental health, 1989
- Dental amalgam and mercuryBioMetals, 1989
- LHRH Analogue Therapy in Infertile Women with Luteal Phase DefectsObstetrical & Gynecological Survey, 1988
- Changes in liver polyamines due to aflatoxin B1Toxicology Letters, 1986
- Effects of sodium selenite on distribution and placental transfer of mercuric mercury in mice of late gestational period.Journal of Pharmacobio-Dynamics, 1981
- Volume 23, 1978 author and subject indexLife Sciences, 1978
- The Transport of Elemental Mercury into Fetal TissuesNeonatology, 1972
- The Influence of Ethyl Alcohol on the Absorption of Mercury Vapour from the Lungs in ManActa Pharmacologica et Toxicologica, 1965