Micro/Nanoparticle‐Augmented Sonodynamic Therapy (SDT): Breaking the Depth Shallow of Photoactivation
Top Cited Papers
- 6 July 2016
- journal article
- review article
- Published by Wiley in Advanced Materials
- Vol. 28 (37), 8097-8129
- https://doi.org/10.1002/adma.201602012
Abstract
The fast development of photoactivation for cancer treatment provides an efficient photo-therapeutic strategy for cancer treatment, but traditional photodynamic or photothermal therapy suffers from the critical issue of low in vivo penetration depth of tissues. As a non-invasive therapeutic modality, sonodynamic therapy (SDT) can break the depth barrier of photoactivation because ultrasound has an intrinsically high tissue-penetration performance. Micro/nanoparticles can efficiently augment the SDT efficiency based on nanobiotechnology. The state-of-art of the representative achievements on micro/nanoparticle-enhanced SDT is summarized, and specific functions of micro/nanoparticles for SDT are discussed, from the different viewpoints of ultrasound medicine, material science and nanobiotechnology. Emphasis is put on the relationship of structure/composition-SDT performance of micro/nanoparticle-based sonosensitizers. Three types of micro/nanoparticle-augmented SDT are discussed, including organic and inorganic sonosensitizers and micro/nanoparticle-based but sonosensitizer-free strategies to enhance the SDT outcome. SDT-based synergistic cancer therapy augmented by micro/nanoparticles and their biosafety are also included. Some urgent critical issues and potential developments of micro/nanoparticle-augmented SDT for efficient cancer treatment are addressed. It is highly expected that micro/nanoparticle-augmented SDT will be quickly developed as a new and efficient therapeutic modality which will find practical applications in cancer treatment. At the same time, fundamental disciplines regarding materials science, chemistry, medicine and nanotechnology will be advanced.Keywords
Funding Information
- Natural Science Foundation of Shanghai (13ZR1463500)
- Youth Innovation Promotion Association of the Chinese Academy of Sciences (2013169)
This publication has 101 references indexed in Scilit:
- DNA-Coated Microbubbles with Biochemically Tunable Ultrasound Contrast ActivityAdvanced Materials, 2011
- Targeted renal therapies through microbubbles and ultrasoundAdvanced Drug Delivery Reviews, 2010
- A microcomposite hydrogel for repeated on-demand ultrasound-triggered drug deliveryBiomaterials, 2010
- In vitro assessments of nanomaterial toxicityAdvanced Drug Delivery Reviews, 2009
- Ratiometric Single‐Nanoparticle Oxygen Sensors for Biological ImagingAngewandte Chemie, 2009
- The biocompatibility of mesoporous silicatesBiomaterials, 2008
- Porous silicon in drug delivery devices and materialsAdvanced Drug Delivery Reviews, 2008
- Ultrasound mediated delivery of drugs and genes to solid tumorsAdvanced Drug Delivery Reviews, 2008
- Microbubbles in ultrasound-triggered drug and gene deliveryAdvanced Drug Delivery Reviews, 2008
- Gold Nanocages for Biomedical ApplicationsAdvanced Materials, 2007