Transmission of Influenza B Viruses in the Guinea Pig
Open Access
- 15 April 2012
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 86 (8), 4279-4287
- https://doi.org/10.1128/jvi.06645-11
Abstract
Epidemic influenza is typically caused by infection with viruses of the A and B types and can result in substantial morbidity and mortality during a given season. Here we demonstrate that influenza B viruses can replicate in the upper respiratory tract of the guinea pig and that viruses of the two main lineages can be transmitted with 100% efficiency between inoculated and naïve animals in both contact and noncontact models. Our results also indicate that, like in the case for influenza A virus, transmission of influenza B viruses is enhanced at colder temperatures, providing an explanation for the seasonality of influenza epidemics in temperate climates. We therefore present, for the first time, a small animal model with which to study the underlying mechanisms of influenza B virus transmission.This publication has 54 references indexed in Scilit:
- Environmental factors affecting the transmission of respiratory virusesCurrent Opinion in Virology, 2012
- Structural basis for the sequence-specific recognition of human ISG15 by the NS1 protein of influenza B virusProceedings of the National Academy of Sciences of the United States of America, 2011
- The need for quadrivalent vaccine against seasonal influenzaVaccine, 2010
- Lambda Interferon Renders Epithelial Cells of the Respiratory and Gastrointestinal Tracts Resistant to Viral InfectionsJournal of Virology, 2010
- Species Specificity of the NS1 Protein of Influenza B VirusOnline Journal of Public Health Informatics, 2010
- Efficacy of live attenuated influenza vaccine in children against influenza B viruses by lineage and antigenic similarityVaccine, 2010
- Mice Lacking the ISG15 E1 Enzyme UbE1L Demonstrate Increased Susceptibility to both Mouse-Adapted and Non-Mouse-Adapted Influenza B Virus InfectionJournal of Virology, 2009
- High Temperature (30°C) Blocks Aerosol but Not Contact Transmission of Influenza VirusJournal of Virology, 2008
- Clinical and genetic characterization of severe influenza B-associated diseases during an outbreak in TaiwanJournal of Clinical Virology, 2008
- The guinea pig as a transmission model for human influenza virusesProceedings of the National Academy of Sciences of the United States of America, 2006