Cyclosporin and tacrolimus increase plasma levels of adenosine in kidney transplanted patients
- 1 March 2005
- journal article
- Published by Frontiers Media SA in Transplant International
- Vol. 18 (3), 289-295
- https://doi.org/10.1111/j.1432-2277.2004.00036.x
Abstract
The immunosuppressive agents, cyclosporin (CsA) and tacrolimus (FK506), display cardioprotective activities. The mechanism would consist on the inhibition of the enzyme, adenosine kinase (AK), leading to an increase in adenosine (ADO) levels. ADO, inosine (INO) and nucleotide plasma levels were measured in kidney transplant recipients before and 1, 2, 4, 6 and 8 h after the administration of CsA or FK506. After CsA and FK506 administration, ADO plasma levels significantly increased, reaching a peak level after 2 h (483 ± 124 and 429 ± 96 nm, respectively), and then progressively declined. Calculated peak values (tmax) of ADO were slightly delayed with respect to those of CsA and FK506. Treatment with rapamycin did not influence the phenomenon. The dynamic profile of plasma changes of ADO, nucleotides and INO were consistent with the inhibition of the enzyme, AK. ADO increase may be clinically relevant in terms of anti-ischaemic, tissue protecting, and immunosuppressive activities as well as in terms of nephrotoxicitKeywords
This publication has 35 references indexed in Scilit:
- Changes of peripheral A2Aadenosine receptors in chronic heart failure and cardiac transplantationThe FASEB Journal, 2002
- Cyclosporin A and FK506 decrease adenosine kinase activity and adenosine uptake in T-lymphocytesJournal of Laboratory and Clinical Medicine, 2002
- Interactions between cyclosporine A and adenosine in kidney transplant recipientsKidney International, 1998
- Endogenous Adenosine Curtails Lipopolysaccharide‐Stimulated Tumour Necrosis Factor SynthesisScandinavian Journal of Immunology, 1997
- Protective Effect of FK506 on Ischemia/Reperfusion-Induced Myocardial Damage in Canine HeartJournal of Cardiovascular Pharmacology, 1993
- THE BENEFICIAL EFFECT OF CYCLOSPORINE ON LIVER ISCHEMIA IN RATSTransplantation, 1989
- Control of human T-lymphocyte interleukin-2 production by a cAMP-dependent pathwayCellular Immunology, 1988
- Engagement of adenosine receptors inhibits hydrogen peroxide (H2O2−) release by activated human neutrophilsClinical Immunology and Immunopathology, 1987
- Cardiovascular effects of adenosine in man; possible clinical implicationsProgress in Neurobiology, 1986
- Myocardial S-adenosylhomocysteine hydrolase is important for adenosine production during normoxiaBiochimica et Biophysica Acta (BBA) - General Subjects, 1985