Chlorogenic Acid Exhibits Cholesterol Lowering and Fatty Liver Attenuating Properties by Up‐regulating the Gene Expression of PPAR‐α in Hypercholesterolemic Rats Induced with a High‐Cholesterol Diet
- 6 June 2012
- journal article
- research article
- Published by Wiley in Phytotherapy Research
- Vol. 27 (4), 545-551
- https://doi.org/10.1002/ptr.4751
Abstract
Hypercholesterolemia is a major risk factor for the development of cardiovascular disease and nonalcoholic fatty liver disease. Natural compounds have been proved to be useful in lowering serum cholesterol to slow down the progression of cardiovascular disease and nonalcoholic fatty liver disease. In the present study, the hypocholesterolemic and hepatoprotective effects of the dietary consumption of chlorogenic acid were investigated by monitoring plasma lipid profile (total cholesterol, triglycerides, high-density lipoprotein and low-density lipoprotein) in Sprague–Dawley rats fed with a normal diet, a high-cholesterol diet or a high-cholesterol diet supplemented with chlorogenic acid (1 or 10 mg/kg/day p.o.) for 28 days. Chlorogenic acid markedly altered the increased plasma total cholesterol and low-density lipoprotein but decreased high-density lipoprotein induced by a hypercholesterolemic diet with a dose-dependent improvement on both atherogenic index and cardiac risk factor. Lipid depositions in liver were attenuated significantly in hypercholesterolemic animals supplemented with chlorogenic acid. It is postulated that hypocholesterolemic effect is the primary beneficial effect given by chlorogenic acid, which leads to other secondary beneficial effects such as atheroscleroprotective, cardioprotective and hepatoprotective functions. The hypocholesterolemic functions of chlorogenic acid are probably due to the increase in fatty acids unitization in liver via the up-regulation of peroxisome proliferation-activated receptor α mRNA. Copyright © 2012 John Wiley & Sons, Ltd.Keywords
This publication has 37 references indexed in Scilit:
- Antihyperlipidemic effect of chlorogenic acid and tetrahydrocurcumin in rats subjected to diabetogenic agentsChemico-Biological Interactions, 2010
- Studies on a chlorogenic acid-producing endophytic fungi isolated from Eucommia ulmoides OliverJournal of Industrial Microbiology & Biotechnology, 2010
- Modulating Effects of Chlorogenic Acid on Lipids and Glucose Metabolism and Expression of Hepatic Peroxisome Proliferator-activated Receptor-α in Golden Hamsters Fed on High Fat DietBiomedical and Environmental Sciences, 2009
- Antioxidant Activity and Lipid-Lowering Effect of Essential Oils Extracted from Ocimum sanctum L. Leaves in Rats Fed with a High Cholesterol DietJournal of Clinical Biochemistry and Nutrition, 2009
- Effects of apple juice on risk factors of lipid profile, inflammation and coagulation, endothelial markers and atherosclerotic lesions in high cholesterolemic rabbitsLipids in Health and Disease, 2009
- Puerarin decreases serum total cholesterol and enhances thoracic aorta endothelial nitric oxide synthase expression in diet-induced hypercholesterolemic ratsLife Sciences, 2006
- Exogenous Thyroid Hormone Induces Liver Enlargement, Whilst Maintaining Regenerative Potential—A Study Relevant to Donor PreconditioningAmerican Journal of Transplantation, 2005
- Oxidized-LDL Enhances Coronary Vasoconstriction by Increasing the Activity of Protein Kinase C Isoforms α and εHypertension, 2001
- High-density lipoprotein inhibits the oxidative modification of low-density lipoproteinBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1990
- Regulation of the mevalonate pathwayNature, 1990