A Review on Antimicrobial Activity of Mushroom (Basidiomycetes) Extracts and Isolated Compounds
- 21 September 2012
- journal article
- review article
- Published by Georg Thieme Verlag KG in Planta Medica
- Vol. 78 (16), 1707-1718
- https://doi.org/10.1055/s-0032-1315370
Abstract
Despite the huge diversity of antibacterial compounds, bacterial resistance to first-choice antibiotics has been drastically increasing. Moreover, the association between multiresistant microorganisms and nosocomial infections highlight the problem, and the urgent need for solutions. Natural resources have been exploited in the last years and among them, mushrooms could be an alternative source of new antimicrobials. In this review, we present an overview of the antimicrobial properties of mushroom extracts and highlight some of the active compounds identified, including low- and high-molecular weight (LMW and HMW, respectively) compounds. LMW compounds are mainly secondary metabolites, such as sesquiterpenes and other terpenes, steroids, anthraquinones, benzoic acid derivatives, and quinolines, but also primary metabolites such as oxalic acid. HMW compounds are mainly peptides and proteins. Data available from the literature indicate a higher antimicrobial activity of mushroom extracts against gram-positive bacteria. Among all the mushrooms, Lentinus edodes is the most studied species and seems to have a broad antimicrobial action against both gram-postive and gram-negative bacteria. Plectasin peptide, obtained from Pseudoplectania nigrella, is the isolated compound with the highest antimicrobial activity against gram-positive bacteria, while 2-aminoquinoline, isolated from Leucopaxillus albissimus, presents the highest antimicrobial activity against gram-negative bacteria.Keywords
This publication has 35 references indexed in Scilit:
- In VitroAssessment of Shiitake Mushroom (Lentinula edodes) Extract for Its Antigingivitis ActivityJournal of Biomedicine and Biotechnology, 2011
- Testing a Low Molecular Mass Fraction of a Mushroom (Lentinus edodes) Extract Formulated as an Oral Rinse in a Cohort of VolunteersJournal of Biomedicine and Biotechnology, 2011
- Effects of Mushroom and Chicory Extracts on the Physiology and Shape ofPrevotella intermedia, a Periodontopathogenic BacteriumJournal of Biomedicine and Biotechnology, 2011
- Screening a mushroom extract library for activity against Acinetobacter baumannii and Burkholderia cepacia and the identification of a compound with anti-Burkholderia activityAnnals of Clinical Microbiology and Antimicrobials, 2010
- Antimicrobial activity of two wild mushroomsClitocybe alexandri (Gill.) Konr. andrhizopogon roseolus (Corda) T.M. Fries collected from TurkeyPhytotherapy Research, 2006
- Antimicrobial Activities of Fruit Bodies and/or Mycelial Cultures of Some Mushroom IsolatesPharmaceutical Biology, 2006
- Antibacterial effect of Phellinus linteus against methicillin-resistant Staphylococcus aureusFitoterapia, 2004
- A ribonuclease with antimicrobial, antimitogenic and antiproliferative activities from the edible mushroom Pleurotus sajor-cajuPeptides, 2004
- Bacterial Wall as Target for AttackClinical Microbiology Reviews, 2003
- Antibacterial Activity of Three Macrofungi,Ganoderma lucidum,Navesporus floccosaandPhellinus rimosusOccurring in South IndiaPharmaceutical Biology, 2003