A case of simvastatin‐induced myopathy with SLCO1B1 genetic predisposition and co‐ingestion of linagliptin and Stevia rebaudiana
- 3 February 2019
- journal article
- research article
- Published by Hindawi Limited in Journal of Clinical Pharmacy & Therapeutics
- Vol. 44 (3), 381-383
- https://doi.org/10.1111/jcpt.12805
Abstract
What is known and objective SLCO1B1 T521>C variant carriers are susceptible to simvastatin‐induced myopathy. We report a patient who developed rhabdomyolysis possibly triggered by a drug–drug and/or herb–drug interaction. Case description A 69‐year‐old man presented with myalgia and weakness progressing to severe rhabdomyolysis. He had been taking 40 mg simvastatin daily for 10 years and recently consumed supplements, including Stevia rebaudiana and linagliptin. Genotyping revealed he carried one copy of SLCO1B1 T521>C and two copies of ABCG2 C421>A. What is new and conclusion Despite apparent long‐term safe administration, co‐ingestion of simvastatin and other CYP3A4 inhibitors may result in severe myopathy in those at increased genetic risk.Keywords
This publication has 15 references indexed in Scilit:
- Racial Differences in the Cholesterol-Lowering Effect of StatinJournal of Atherosclerosis and Thrombosis, 2017
- Impact of CYP2D6, CYP3A5, CYP2C19, CYP2A6, SLCO1B1, ABCB1, and ABCG2 gene polymorphisms on the pharmacokinetics of simvastatin and simvastatin acidPharmacogenetics and Genomics, 2015
- Statin-associated muscle symptoms: impact on statin therapy—European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and ManagementEuropean Heart Journal, 2015
- Impact of ABCG2 and SLCO1B1 polymorphisms on pharmacokinetics of rosuvastatin, atorvastatin and simvastatin acid in Caucasian and Asian subjects: a class effect?European Journal of Clinical Pharmacology, 2015
- The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1 and Simvastatin-Induced Myopathy: 2014 UpdateCancer Cell, 2014
- HPS2-THRIVE randomized placebo-controlled trial in 25 673 high-risk patients of ER niacin/laropiprant: trial design, pre-specified muscle and liver outcomes, and reasons for stopping study treatmentEuropean Heart Journal, 2013
- The Clinical Pharmacogenomics Implementation Consortium: CPIC Guideline for SLCO1B1 and Simvastatin-Induced MyopathyCancer Cell, 2012
- Different Effects of the ABCG2 C.421C>A SNP on the Pharmacokinetics of Fluvastatin, Pravastatin and SimvastatinPharmacogenomics, 2009
- SLCO1B1 variants and statin-induced myopathy - A genomewide studyNew England Journal of Medicine, 2008
- Sustained Reduction of Serum Cholesterol in Low-Dose 6-Year Simvastatin Treatment With Minimum Side Effects in 51,321 Japanese Hypercholesterolemic PatientsCirculation Journal, 2003