Beyond Repeated-Measures Analysis of Variance
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- 1 January 2012
- journal article
- research article
- Published by BMJ in Regional Anesthesia & Pain Medicine
- Vol. 37 (1), 99-105
- https://doi.org/10.1097/aap.0b013e31823ebc74
Abstract
Background and Objectives Research in the field of anesthesiology relies heavily on longitudinal designs for answering questions about long-term efficacy and safety of various anesthetic and pain regimens. Yet, anesthesiology research is lagging in the use of advanced statistical methods for analyzing longitudinal data. The goal of this article was to increase awareness of the advantages of modern statistical methods and promote their use in anesthesia research. Methods Here we introduce 2 modern and advanced statistical methods for analyzing longitudinal data: the generalized estimating equations (GEE) and mixed-effects models (MEM). These methods were compared with the conventional repeated-measures analysis of variance (RM-ANOVA) through a clinical example with 2 types of end points (continuous and binary). In addition, we compared GEE and MEM to RM-ANOVA through a simulation study with varying sample sizes, varying number of repeated measures, and scenarios with and without missing data. Results In the clinical study, the 3 methods are found to be similar in terms of statistical estimation, whereas the parameter interpretations are somewhat different. The simulation study shows that the methods of GEE and MEM are more efficient in that they are able to achieve higher power with smaller sample size or lower number of repeated measurements in both complete and missing data scenarios. Conclusions Based on their advantages over RM-ANOVA, GEE and MEM should be strongly considered for the analysis of longitudinal data. In particular, GEE should be used to explore overall average effects, and MEM should be used when subject-specific effects (in addition to overall average effects) are of primary interest.Keywords
This publication has 21 references indexed in Scilit:
- Evaluation of the Depth and Duration of Anesthesia From Heated Lidocaine/Tetracaine (Synera) Patches Compared With Placebo Patches Applied to Healthy Adult VolunteersRegional Anesthesia & Pain Medicine, 2010
- Ultrasound-Guided Evaluation of the Local Anesthetic Spread Parameters Required for a Rapid Surgical Popliteal Sciatic Nerve BlockRegional Anesthesia & Pain Medicine, 2010
- A Randomized Comparison Between Ultrasound-Guided and Landmark-Based Superficial Cervical Plexus BlockRegional Anesthesia & Pain Medicine, 2010
- Comparison of 2% Mepivacaine, Clipping, and Radiofrequency Thermocoagulation for Duration and Magnitude of Action in Peripheral Arterial Blood Flow Induced by Sympathetic Block in Anesthetized DogsRegional Anesthesia & Pain Medicine, 2010
- Perioperative Pulmonary Circulatory Changes During Bilateral Total Hip Arthroplasty Under Regional AnesthesiaRegional Anesthesia & Pain Medicine, 2010
- Perineural Dexmedetomidine Provides an Increased Duration of Analgesia to a Thermal Stimulus When Compared With a Systemic Control in a Rat Sciatic Nerve BlockRegional Anesthesia & Pain Medicine, 2010
- Comparison of Bupivacaine, Ropivacaine, and Levobupivacaine in an Equal Dose and Concentration for Sympathetic Block in DogsRegional Anesthesia & Pain Medicine, 2010
- An Overview of Practical Approaches for Handling Missing Data in Clinical TrialsJournal of Biopharmaceutical Statistics, 2009
- Analysis of Semiparametric Regression Models for Repeated Outcomes in the Presence of Missing DataJournal of the American Statistical Association, 1995
- THE MULTICENTER AIDS COHORT STUDY: RATIONALE, ORGANIZATION, AND SELECTED CHARACTERISTICS OF THE PARTICIPANTSAmerican Journal of Epidemiology, 1987