Gastrointestinal regulatory peptides and central nervous system mechanisms of weight control
- 1 February 2012
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Current Opinion in Endocrinology, Diabetes and Obesity
- Vol. 19 (1), 13-18
- https://doi.org/10.1097/med.0b013e32834ea723
Abstract
This review focuses on recent advances in understanding the multiple roles of gastrointestinal peptides in the control of food intake and body weight with specific emphasis on ghrelin, amylin and glucagon-like peptide 1. Recent studies support a role for ghrelin, amylin and glucagon-like peptide 1 in short-term and long-term effects on food intake and body weight. Apart from contributing to energy homeostasis, ghrelin's participation in reward and sensory processing has been the focus of much recent work. New findings on amylin's effects on food intake and energy balance provide further support for its role in meal-related food intake and suggest that it may also function as an adiposity signal. New investigations on the role of central and peripheral glucagon-like peptide 1 receptors in mediating the anorexic effects of glucagon-like peptide 1 have suggested that they differentially contribute to short-term and long term effects on food intake. Gastrointestinal peptides can influence food intake through mechanisms that involve short-term meal-related effects or through activation of central pathways involved in energy balance. An appreciation of the multiple actions of gastrointestinal peptides on food intake will aid in developing new strategies for weight management.Keywords
This publication has 69 references indexed in Scilit:
- Maintenance on a high-fat diet impairs the anorexic response to glucagon-like-peptide-1 receptor activationPhysiology & Behavior, 2011
- Ghrelin mediates stress-induced food-reward behavior in miceJCI Insight, 2011
- Glucose and Weight Control in Mice with a Designed Ghrelin O-Acyltransferase InhibitorScience, 2010
- Central amylin acts as an adiposity signal to control body weight and energy expenditurePhysiology & Behavior, 2010
- Ghrelin increases intake of rewarding food in rodentsAddiction Biology, 2010
- Ghrelin receptor antagonism attenuates cocaine- and amphetamine-induced locomotor stimulation, accumbal dopamine release, and conditioned place preferencePsychopharmacology, 2010
- Sensitivity to the satiating effects of exendin 4 is decreased in obesity-prone Osborne–Mendel rats compared to obesity-resistant S5B/Pl ratsInternational Journal of Obesity, 2010
- Enhanced Weight Loss With Pramlintide/Metreleptin: An Integrated Neurohormonal Approach to Obesity PharmacotherapyObesity, 2009
- Leptin responsiveness restored by amylin agonism in diet-induced obesity: Evidence from nonclinical and clinical studiesProceedings of the National Academy of Sciences of the United States of America, 2008
- Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetiteJCI Insight, 2006