Mechanisms controlling granule-mediated cytolytic activity of cytotoxic T lymphocytes
- 6 November 2011
- journal article
- review article
- Published by Springer Science and Business Media LLC in Immunologic Research
- Vol. 51 (2-3), 183-194
- https://doi.org/10.1007/s12026-011-8252-8
Abstract
Cytotoxic T lymphocytes (CTL) play a critical role in immunity against viruses and cancer. The antigen receptor or T-cell receptor (TCR) on CTL determines the specificity toward target cells. The CD8 co-receptor functions in concert with the TCR to enhance TCR-mediated signaling, accounting for the remarkable sensitivity and swift signaling kinetics of the CTL response. The latter ensures efficient delivery and release of lytic granules, resulting in sensitive and rapid destruction of target cells.Keywords
This publication has 101 references indexed in Scilit:
- A Single T Cell Receptor Bound to Major Histocompatibility Complex Class I and Class II Glycoproteins Reveals Switchable TCR ConformersImmunity, 2011
- Two-Stage Cooperative T Cell Receptor-Peptide Major Histocompatibility Complex-CD8 Trimolecular Interactions Amplify Antigen DiscriminationImmunity, 2011
- The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsivenessNature, 2010
- TCR–peptide–MHC interactions in situ show accelerated kinetics and increased affinityNature, 2010
- Kinetics of Early T Cell Receptor Signaling Regulate the Pathway of Lytic Granule Delivery to the Secretory DomainImmunity, 2009
- The Strength of T Cell Receptor Signal Controls the Polarization of Cytotoxic Machinery to the Immunological SynapseImmunity, 2009
- How much can a T-cell antigen receptor adapt to structurally distinct antigenic peptides?The EMBO Journal, 2007
- Recruitment of dynein to the Jurkat immunological synapseProceedings of the National Academy of Sciences of the United States of America, 2006
- Cytotoxic T lymphocytes kill multiple targets simultaneously via spatiotemporal uncoupling of lytic and stimulatory synapsesProceedings of the National Academy of Sciences of the United States of America, 2006
- Agonist/endogenous peptide–MHC heterodimers drive T cell activation and sensitivityNature, 2005