Model‐Informed Precision Dosing at the Bedside: Scientific Challenges and Opportunities
Top Cited Papers
Open Access
- 16 October 2018
- journal article
- research article
- Published by Wiley in CPT: Pharmacometrics & Systems Pharmacology
- Vol. 7 (12), 785-787
- https://doi.org/10.1002/psp4.12353
Abstract
The development of model‐informed precision dosing (MIPD) tools, especially in the form of native or web‐based applications to be used at the bedside, has garnered marked attention in recent years. Their potential clinical benefit can be large1, but it should be ensured that such tools make optimal use of available clinical data and have adequate predictive ability. Unique scientific challenges specific to MIPD remain which may require adaptation of commonly used diagnostics in pharmacometrics.Keywords
This publication has 9 references indexed in Scilit:
- Bayesian Estimation of Tobramycin Exposure in Patients with Cystic Fibrosis: an UpdateAntimicrobial Agents and Chemotherapy, 2018
- The Time is Now: Model-Based Dosing to Optimize Drug TherapyInternational Journal of Pharmacokinetics, 2017
- Precision Dosing: Public Health Need, Proposed Framework, and Anticipated ImpactClinical and Translational Science, 2017
- Why Has Model‐Informed Precision Dosing Not Yet Become Common Clinical Reality? Lessons From the Past and a Roadmap for the FutureClinical Pharmacology & Therapeutics, 2017
- Impact of Laboratory Practices on Interlaboratory Variability in Therapeutic Drug Monitoring of Immunosuppressive DrugsTherapeutic Drug Monitoring, 2015
- Computerized advice on drug dosage to improve prescribing practiceCochrane Database of Systematic Reviews, 2013
- Pitfalls in TDM of Antibiotic Drugs: Analytical and Modelling IssuesTherapeutic Drug Monitoring, 2006
- Inherent Correlation Between Dose and Clearance in Therapeutic Drug Monitoring Settings: Possible Misinterpretation in Population Pharmacokinetic AnalysesJournal of Pharmacokinetics and Pharmacodynamics, 2005
- Computer-aided long-term anticoagulation therapyComputers and Biomedical Research, 1969