Gender differences in the association between antidepressant use and restless legs syndrome
- 15 May 2009
- journal article
- clinical trial
- Published by Wiley in Movement Disorders
- Vol. 24 (7), 1054-1059
- https://doi.org/10.1002/mds.22517
Abstract
Contradictory results have been reported for the association between antidepressant use and Restless Legs Syndrome (RLS). Our aim was to clarify the relationship and examine possible gender differences. We interviewed 1,693 veterans receiving primary care from the Cleveland VA Medical Center and obtained prescription drug information from their medical records. Overall, use of an antidepressant was associated with RLS for men (RR = 1.77, CI = 1.26, 2.48) but not for women (RR = 0.79, CI = 0.43, 1.47). Analyses of individual antidepressants revealed an association between RLS and fluoxetine for women (RR = 2.47, CI = 1.33, 4.56), and associations between RLS and citalopram, (RR = 2.09, CI = 1.20, 3.64), paroxetine (RR = 1.97, CI = 1.02, 3.79), and amitriptyline (RR = 2.40, CI = 1.45, 4.00) for men. We conclude that RLS may be associated with antidepressant use, but the association varies by gender and type of antidepressant. Antidepressant use is more strongly associated with RLS in men than in women. © 2009 Movement Disorder SocietyFunding Information
- US Army Medical Research and Materiel Command (DAMD17-03-1-0082)
- Pfizer Pharmaceutical Corporation
This publication has 29 references indexed in Scilit:
- Erratum to “Restless legs syndrome induced by citalopram: a psychiatric emergency?” [General Hospital Psychiatry 29 (2007) 72–74]General Hospital Psychiatry, 2007
- Fluoxetine-Mirtazapine Interaction May Induce Restless Legs SyndromePublished by Physicians Postgraduate Press, Inc ,2006
- Does domperidone potentiate mirtazapine-associated restless legs syndrome?Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2006
- Restless Legs Syndrome, Periodic Limb Movements in Sleep, and DepressionSleep, 2005
- Restless Legs Syndrome Induced by MirtazapinePublished by Physicians Postgraduate Press, Inc ,2002
- Síndrome das pernas inquietas com herança autossômica dominante piorada pelo uso de mirtazapina: relato de casoArquivos de Neuro-Psiquiatria, 2002
- Mirtazapine may have the propensity for developing a restless legs syndrome? A case reportPsychiatry and Clinical Neurosciences, 2002
- Restless Leg Syndrome Exacerbated by SertralinePsychosomatics, 1998
- Restless legs syndrome and paroxetineActa Psychiatrica Scandinavica, 1996
- Fluoxetine and restless legs syndromeJournal of the Neurological Sciences, 1996