Progressive arthropathy in mice with a targeted disruption of theMop3/Bmal-1 locus
- 7 March 2005
- Vol. 41 (3), 122-132
- https://doi.org/10.1002/gene.20102
Abstract
Disruption of the murine Mop3 (also known as Bmal1 or Arntl) locus results in a loss of behavioral and molecular circadian rhythms. Although Mop3 null mice do not display anomalies in early development, they do display reduced activity as they age. In an effort to explain this decreased activity, we characterized the physiological and anatomical changes that occurred with age. We observed that Mop3 null mice display an increased mortality after 26 weeks of age and a phenotype best described as a progressive noninflammatory arthropathy. Although little pathology is observed prior to 11 weeks of age, by 35 weeks of age essentially all Mop3 null animals develop joint ankylosis due to flowing ossification of ligaments and tendons and almost complete immobilization of weight-bearing and nonweight-bearing joints. This pathology appears to explain the decreased activity of Mop3 null mice and suggests that MOP3 is an inhibitor of ligament and tendon ossification. genesis 41:122–132, 2005.Keywords
This publication has 29 references indexed in Scilit:
- Stopping Time: The Genetics of Fly and Mouse Circadian ClocksAnnual Review of Neuroscience, 2001
- Role of the Mouse ank Gene in Control of Tissue Calcification and ArthritisScience, 2000
- T lymphocytes are not required for the spontaneous development of entheseal ossification leading to marginal ankylosis in the DBA/1 mouseArthritis & Rheumatism, 2000
- Role of the CLOCK Protein in the Mammalian Circadian MechanismScience, 1998
- The basic-helix–loop–helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factorsProceedings of the National Academy of Sciences of the United States of America, 1998
- cDNA Cloning and Tissue-Specific Expression of a Novel Basic Helix–Loop–Helix/PAS Protein (BMAL1) and Identification of Alternatively Spliced Variants with Alternative Translation Initiation Site UsageBiochemical and Biophysical Research Communications, 1997
- Arthritis and ankylosis in twy mice with hereditary multiple osteochondral lesions: With special reference to calcium depositionPathology International, 1994
- Progressive ankylosis in miceArthritis & Rheumatism, 1988
- A Rapid Method for Preparing High Quality Alizarin Stained Skeletons of Adult MiceStain Technology, 1987
- Adrenal/parathyroid regulation of DNA, collagen and protein synthesis in rat epiphysial cartilage and boneJournal of Endocrinology, 1984