Parity and decreased use of oral contraceptives as predictors of asthma in young women
- 29 March 2006
- journal article
- Published by Wiley in Clinical & Experimental Allergy
- Vol. 36 (5), 609-613
- https://doi.org/10.1111/j.1365-2222.2006.02475.x
Abstract
Background Asthma is more prevalent among males in childhood, but females report higher rates in adulthood. The reasons are unknown; although it has been hypothesized that hormonal factors may explain this sex‐dependent risk of adult‐onset asthma. Objective To determine whether a woman's reproductive history or use of oral contraceptives is associated with adult‐onset asthma. Methods In 1991–1993, we surveyed 681 women aged 29–32 years randomly sampled from participants first surveyed at age 7 years by the 1968 Tasmanian Asthma Survey, a study of all children born in 1961 and attending school. Current asthma was defined as reporting asthma or wheezy breathing in the past 12 months. Results In women who did not have asthma or wheezy breathing by age 7 years, 13% had current asthma. The risk of current asthma in these who were parous increased with the number of births (odds ratio (OR) 1.50 per birth, 95% confidence interval (CI) 1.01–2.23 P=0.04) while women with one birth were at a lower risk than nulliparous women (OR 0.46 95% CI 0.2–1.06, P=0.07). Independent of parity, the risk decreased by 7% (95% CI 0–13%) per year of oral contraceptive pill use in all women. In women who did have asthma or wheezy breathing by age 7 years, neither reproductive history nor oral contraceptive pill use predicted current asthma. Conclusion Our observation that parity and decreased oral contraceptive use predict asthma in women, is consistent with the hypothesis that the asthma that develops after childhood is in part a response to endogenous and exogenous female hormones. This may be due to alterations of cytokine responses by the pregnant state, triggering adult‐onset asthma in women.Keywords
This publication has 15 references indexed in Scilit:
- AsthmaThe New England Journal of Medicine, 2001
- Differences in Incidence of Reported Asthma Related to Age in Men and WomenAmerican Journal of Respiratory and Critical Care Medicine, 2000
- Gender differences in airway behaviour over the human life spanThorax, 1999
- Validation of Questionnaire and Bronchial Hyperresponsiveness against Respiratory Physician Assessment in the Diagnosis of AsthmaInternational Journal of Epidemiology, 1996
- The influence of age, diagnosis, and gender on proper use of metered-dose inhalers.American Journal of Respiratory and Critical Care Medicine, 1994
- Challenges in interpreting gender differences in asthma.American Journal of Respiratory and Critical Care Medicine, 1994
- Factors in childhood as predictors of asthma in adult lifeBMJ, 1994
- Rates of admission to hospital for asthmaBMJ, 1994
- The associations between childhood asthma and atopy, and parental asthma, hay fever and smokingPaediatric and Perinatal Epidemiology, 1993
- Effects of Female Hormones on the Muscarinic and α1-Adrenergic Receptors of the Nasal MucosaORL, 1986