Emergence of a Clinical Daptomycin-Resistant Staphylococcus aureus Isolate during Treatment of Methicillin-Resistant Staphylococcus aureus Bacteremia and Osteomyelitis
Open Access
- 1 February 2006
- journal article
- case report
- Published by American Society for Microbiology in Journal of Clinical Microbiology
- Vol. 44 (2), 395-399
- https://doi.org/10.1128/jcm.44.2.595-597.2006
Abstract
The emergence of a clinically daptomycin-resistant Staphylococcus aureus isolate occurred during treatment of methicillin-resistant S. aureus bacteremia and probable vertebral osteomyelitis. The breakthrough isolate was indistinguishable from pretreatment daptomycin-susceptible isolates by pulsed-field gel electrophoresis. Daptomycin nonsusceptibility was confirmed by MIC and time-kill curve analyses.Keywords
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