Polymorphisms in GSDMA and GSDMB are associated with asthma susceptibility, atopy and BHR
- 18 February 2011
- journal article
- research article
- Published by Wiley in Pediatric Pulmonology
- Vol. 46 (7), 701-708
- https://doi.org/10.1002/ppul.21424
Abstract
The gasdermin A (GSDMA) and gasdermin B (GSDMB) genes are located at 17q21.2. The GSDM family genes have been studied in the gastrointestinal tract but recent reports suggest that GSDMB is associated with childhood asthma in several populations. We investigated the association of the GSDMA and GSDMB variants with asthma in Korean children, and to assess the effect of these variants on intermediate phenotypes of asthma. Asthmatic (n = 778) and normal (n = 522) children were enrolled and genotypes were determined using PCR-RFLP. Asthma susceptibility was associated with GG of the GSDMA (rs7212938) and TT of GSDMB (rs7216389). And a combination of risk alleles of two polymorphisms was associated with asthma susceptibility and a frequency of those was higher in asthmatic children with increased levels of total IgE (aOR 1.77, 95% CI 1.15–2.72) and BHR (aOR 1.54, 95% CI 0.99–2.40) compared to normal. Also, we observed a significant association between haplotype of two polymorphisms and asthma susceptibility. The region including the GSDMA and GSDMB polymorphisms may be associated with asthma susceptibility and intermediate phenotypes of asthma, such as elevated IgE and BHR, in Korean children with asthma. These results strongly support an important role for the GSDMA and GSDMB in the development of childhood asthma. Pediatr. Pulmonol. 2011; 46:701–708.Keywords
Funding Information
- Korea Healthcare Technology R&D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea (A084144)
This publication has 23 references indexed in Scilit:
- A sequence variant on 17q21 is associated with age at onset and severity of asthmaEuropean Journal of Human Genetics, 2010
- Orm family proteins mediate sphingolipid homeostasisNature, 2010
- The asthma-associated ORMDL3 gene product regulates endoplasmic reticulum-mediated calcium signaling and cellular stressHuman Molecular Genetics, 2009
- Allele-Specific Chromatin Remodeling in the ZPBP2/GSDMB/ORMDL3 Locus Associated with the Risk of Asthma and Autoimmune DiseaseAmerican Journal of Human Genetics, 2009
- Genetic variation in ORM1‐like 3 (ORMDL3) and gasdermin‐like (GSDML) and childhood asthmaAllergy, 2009
- Effect of 17q21 Variants and Smoking Exposure in Early-Onset AsthmaNew England Journal of Medicine, 2008
- ORMDL3 Gene Is Associated with Asthma in Three Ethnically Diverse PopulationsAmerican Journal of Respiratory and Critical Care Medicine, 2008
- Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthmaNature, 2007
- Asthma genetics 2006: the long and winding road to gene discoveryGenes & Immunity, 2006
- The immunogenetics of asthma and eczema: a new focus on the epitheliumNature Reviews Immunology, 2004