Thermal Degradation of DNA
- 1 June 2013
- journal article
- research article
- Published by Mary Ann Liebert Inc in DNA and Cell Biology
- Vol. 32 (6), 298-301
- https://doi.org/10.1089/dna.2013.2056
Abstract
In this article, we investigate the thermal degradation of deoxyribonucleic acid (DNA). We find that under dry conditions, complete DNA degradation occurs at above 190°C. In addition, as the boiling temperature of water is pressure dependent, we have investigated the thermal degradation of the DNA in water for different applied partial pressures. This information is important for fundamental understanding of DNA structure and energetics, and can be useful for biomedical applications such as thermal targeting of DNA in cancer cells, as well as for basic research.Keywords
This publication has 8 references indexed in Scilit:
- DNA Double-Strand Breaks Induced by Cavitational Mechanical Effects of Ultrasound in Cancer Cell LinesPLOS ONE, 2012
- Thermomechanics of DNA: Theory of Thermal Stability under LoadPhysical Review Letters, 2011
- Targeting the DNA Double Strand Break Repair Machinery in Prostate CancerPLOS ONE, 2011
- Spatiotemporal characterization of ionizing radiation induced DNA damage foci and their relation to chromatin organizationMutation research. Reviews in mutation research, 2010
- γH2AX foci analysis for monitoring DNA double-strand break repair: Strengths, limitations and optimizationCell Cycle, 2010
- Mutational Analysis of the Locus of Enterocyte Effacement-Encoded Regulator (Ler) of EnteropathogenicEscherichia coliJournal of Bacteriology, 2008
- Base-stacking and base-pairing contributions into thermal stability of the DNA double helixNucleic Acids Research, 2006
- Thermal Stability of Human DNA and Chimpanzee DNA HeteroduplexesScience, 1976