Among the estimated 34 million contact lens wearers in the United States,1 microbial keratitis (corneal infection) is a rare but serious complication that may lead to permanent vision loss or the need for corneal transplantation. The risk of microbial keratitis among contact lens wearers is about 80-fold greater than among healthy nonwearers.2 Risk factors for contact lens–associated microbial keratitis include extended wear soft lenses, overnight contact lens wear, and suboptimal adherence to recommended lens wear and care regimens.2-8 Annual incidence of microbial keratitis is estimated to be 4 to 21 per 10 000 soft contact lens wearers depending on overnight wear.9-11