Development of a Rapid and Convenient Method for Determination of Rubella Virus-Specific Immunoglobulin G Avidity
- 1 November 2007
- journal article
- Published by American Society for Microbiology in Clinical and Vaccine Immunology
- Vol. 14 (11), 1416-1419
- https://doi.org/10.1128/cvi.00312-07
Abstract
We describe here a rapid and semiautomated method for the determination of rubella virus immunoglobulin G (IgG) avidity with the VIDAS instrument. A total of 153 serum samples from persons with naturally acquired rubella virus infections ( n = 98), from vaccinated persons ( n = 44), and from patients with autoantibodies ( n = 11) were included in this study. The rubella virus-specific IgG avidity assay we developed for the VIDAS instrument was evaluated by comparison with an in-house method. Results obtained with the VIDAS instrument allow considering this method valuable to help confirm or exclude acute primary infection or recent vaccination.Keywords
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