Gender and Outcome in Adult Congenital Heart Disease
- 1 July 2008
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Circulation
- Vol. 118 (1), 26-32
- https://doi.org/10.1161/circulationaha.107.758086
Abstract
Background— Gender differences in prognosis have frequently been reported in cardiovascular disease but less so in congenital heart disease. We investigated whether gender is associated with outcome in adult patients with congenital heart disease. Methods and Results— From the CONgenital CORvitia (CONCOR) national registry for adults with congenital heart disease, 7414 patients were identified. All outcomes before entry into the registry and during subsequent follow-up were recorded, and differences between men and women were analyzed with the underlying congenital heart defect taken into account. Median age at the end of follow-up was 35 years (range, 17 to 91 years); 49.8% were female. No gender difference in mortality was found. Women had a 33% higher risk of pulmonary hypertension (odds ratio [OR]=1.33; 95% CI, 1.07 to 1.65; P=0.01), a 33% lower risk of aortic outcomes (OR=0.67; 95% CI, 0.50 to 0.90; P=0.007), a 47% lower risk of endocarditis (OR=0.53; 95% CI, 0.40 to 0.70; PP=0.006). Furthermore, the risk of arrhythmias appeared to be lower in women (OR=0.88; 95% CI, 0.77 to 1.02; P=0.08). Conclusions— The risk of several major cardiac outcomes in adult patients with congenital heart disease appears to vary by gender.This publication has 34 references indexed in Scilit:
- Pulmonary arterial hypertension in adults born with a heart septal defect: the Euro Heart Survey on adult congenital heart diseaseHeart, 2007
- Gender Differences in the Treatment for Acute Myocardial InfarctionCirculation, 2007
- The relation between family socioeconomic trajectories from childhood to adolescence and dental caries and associated oral behavioursJournal of Epidemiology and Community Health, 2007
- Determinants of operative mortality in valvular heart surgeryThe Journal of Thoracic and Cardiovascular Surgery, 2006
- Aortic Root Growth in Men and Women With the Marfan’s SyndromeThe American Journal of Cardiology, 2005
- Female-specific aspects in the pharmacotherapy of chronic cardiovascular diseasesEuropean Heart Journal, 2005
- CONCOR, an initiative towards a national registry and DNA-bank of patients with congenital heart disease in the Netherlands: Rationale, design, and first resultsEuropean Journal of Epidemiology, 2005
- Is there a sex bias in implantable cardioverter-defibrillator referral and prescription?Heart, 2004
- Sudden unexpected death in children with a previously diagnosed cardiovascular disorderInternational Journal of Cardiology, 2004
- Influence of gender, race, and education on patient preferences and receipt of cardiac catheterizations among coronary care unit patientsThe American Journal of Cardiology, 1996