The Role of the Liver in Sepsis
Top Cited Papers
- 10 March 2014
- journal article
- review article
- Published by Taylor & Francis Ltd in International Reviews of Immunology
- Vol. 33 (6), 498-510
- https://doi.org/10.3109/08830185.2014.889129
Abstract
Despite the progress made in the clinical management of sepsis, sepsis morbidity and mortality rates remain high. The inflammatory pathogenesis and organ injury leading to death from sepsis are not fully understood for vital organs, especially the liver. Only recently has the role of the liver in sepsis begun to be revealed. Pre-existing liver dysfunction is a risk factor for the progression of infection to sepsis. Liver dysfunction after sepsis is an independent risk factor for multiple organ dysfunction and sepsis-induced death. The liver works as a lymphoid organ in response to sepsis. Acting as a double-edged sword in sepsis, the liver-mediated immune response is responsible for clearing bacteria and toxins but also causes inflammation, immunosuppression, and organ damage. Attenuating liver injury and restoring liver function lowers morbidity and mortality rates in patients with sepsis. This review summarizes the central role of liver in the host immune response to sepsis and in clinical outcomes.Keywords
This publication has 60 references indexed in Scilit:
- Lipopolysaccharide Clearance, Bacterial Clearance, and Systemic Inflammatory Responses Are Regulated by Cell Type–Specific Functions of TLR4 during SepsisThe Journal of Immunology, 2013
- Bench-to-bedside review: Natural killer cells in sepsis - guilty or not guilty?Critical Care, 2013
- Liver Dysfunction and Phosphatidylinositol-3-Kinase Signalling in Early Sepsis: Experimental Studies in Rodent Models of PeritonitisPLoS Medicine, 2012
- Population Burden of Long‐Term Survivorship After Severe Sepsis in Older AmericansJournal of the American Geriatrics Society, 2012
- Innate Response Activator B Cells Protect Against Microbial SepsisScience, 2012
- Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell functionThe Journal of Experimental Medicine, 2010
- Severe sepsis in cirrhosisJournal of Hepatology, 2009
- Chronic Liver Disease Impairs Bacterial Clearance in a Human Model of Induced BacteremiaClinical and Translational Science, 2009
- Incidence, organ dysfunction and mortality in severe sepsis: a Spanish multicentre studyCritical Care, 2008
- CD8+ T Cells Promote Inflammation and Apoptosis in the Liver after Sepsis: Role of Fas-FasLThe American Journal of Pathology, 2007