Brain development in autism: Early overgrowth followed by premature arrest of growth
- 1 May 2004
- journal article
- review article
- Published by Wiley in Mental Retardation and Developmental Disabilities Research Reviews
- Vol. 10 (2), 106-111
- https://doi.org/10.1002/mrdd.20020
Abstract
Due to the relatively late age of clinical diagnosis of autism, the early brain pathology of children with autism has remained largely unstudied. The increased use of retrospective measures such as head circumference, along with a surge of MRI studies of toddlers with autism, have opened a whole new area of research and discovery. Recent studies have now shown that abnormal brain overgrowth occurs during the first 2 years of life in children with autism. By 2–4 years of age, the most deviant overgrowth is in cerebral, cerebellar, and limbic structures that underlie higher‐order cognitive, social, emotional, and language functions. Excessive growth is followed by abnormally slow or arrested growth. Deviant brain growth in autism occurs at the very time when the formation of cerebral circuitry is at its most exuberant and vulnerable stage, and it may signal disruption of this process of circuit formation. The resulting aberrant connectivity and dysfunction may lead to the development of autistic behaviors. To discover the causes, neural substrates, early‐warning signs and effective treatments of autism, future research should focus on elucidating the neurobiological defects that underlie brain growth abnormalities in autism that appear during these critical first years of life. MRDD Research Reviews 2004;10:106–111.Keywords
This publication has 53 references indexed in Scilit:
- Association of the homeobox transcription factor, ENGRAILED 2, 3, with autism spectrum disorderMolecular Psychiatry, 2004
- Relationship Between Head Circumference and Brain Volume in Healthy Normal Toddlers, Children, and AdultsNeuropediatrics, 2002
- Cerebral Lobes in Autism: Early Hyperplasia and Abnormal Age EffectsNeuroImage, 2002
- Regulation of Cerebral Cortical Size by Control of Cell Cycle Exit in Neural PrecursorsScience, 2002
- Head circumference in autism, Asperger syndrome, and ADHD: a comparative studyDevelopmental Medicine and Child Neurology, 2002
- Neuropsychological consequences of cerebellar tumour resection in childrenBrain, 2000
- Prediction and preparation, fundamental functions of the cerebellum.Learning & Memory, 1997
- Attentional Activation of the Cerebellum Independent of Motor InvolvementScience, 1997
- Can Autism be Detected at 18 Months?The British Journal of Psychiatry, 1992
- STRUCTURAL ORGANIZATION OF THE HUMAN CEREBRAL CORTEX. 1.Cells Tissues Organs, 1961