Generation of unique mono-hydroxy-eicosatetraenoic acids from arachidonic acid by human neutrophils.
Open Access
- 1 August 1979
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 150 (2), 406-411
- https://doi.org/10.1084/jem.150.2.406
Abstract
Incubation of [3H]arachidonic acid with the 17,000 g supernatant from homogenates of human neutrophils in the presence of indomethacin generated the unique metabolites 9-OH-5,7,11,14-eicosatetraenoic acid (9-HETE) and 8-HETE, in addition to 12-HETE, 11-HETE and 5-HETE. The human neutrophil chemotactic activity of the HETE products exhibited a rank-order of potency with 5-HETE .mchgt. 8-HETE = 9-HETE > 11-HETE = 12-HETE. The expression of chemokinetic activity and chemotactic activity suggested that the endogenous production of these principles may influence the mobility of human neutrophils.This publication has 7 references indexed in Scilit:
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