The MHC class I ligand‐generating system: roles of immunoproteasomes and the interferon‐4gMY‐inducible proteasome activator PA28
- 1 June 1998
- journal article
- review article
- Published by Wiley in Immunological Reviews
- Vol. 163 (1), 161-176
- https://doi.org/10.1111/j.1600-065x.1998.tb01195.x
Abstract
Production of antigenic peptides that serve as MHC class I ligands is essential for initiation of cell-mediated immunity. Accumulating evidence indicates that the proteasome, a large multisubunit protein deg radative machine in eukaryotes, functions as a processing enzyme responsible for the generation of MHC class I ligands. This processing system is elaborately regulated by various immunomodulatory cytokines. In particular, interferon-gamma induces the formation of immunoproteasomes and a recently identified proteasomal regulatory factor. PA28, which in concert contribute to efficient production of MHC class I ligands. Many of the MHC-encoded genes including LMP appear to have emerged by an ancient chromosomal duplication, suggesting that modifications and renewal of pre-existing non-immune genes were instrumental in the emergence of adaptive immunity.Keywords
This publication has 128 references indexed in Scilit:
- Immunoproteasome Assembly: Cooperative Incorporation of Interferon γ (IFN-γ)–inducible SubunitsThe Journal of Experimental Medicine, 1998
- DNA Sequence, Chromosomal Localization, and Tissue Expression of the Mouse Proteasome SubunitLmp10(Psmb10) GeneGenomics, 1997
- Rapamycin inhibits proteasome activator expression and proteasome activityEuropean Journal of Immunology, 1997
- Genetic Relationships of the Genes Encoding the Human Proteasome β Subunits and the Proteasome PA28 ComplexGenomics, 1997
- Structure of 20S proteasome from yeast at 2.4Å resolutionNature, 1997
- Paralogy Mapping: Identification of a Region in the Human MHC Triplicated onto Human Chromosomes 1 and 9 Allows the Prediction and Isolation of NovelPBXandNOTCHLociGenomics, 1996
- Proteasome components with reciprocal expression to that of the MHC-encoded LMP proteinsCurrent Biology, 1994
- Genomic organization of the mouse Lmp-2 gene and characteristic structure of its promoterGene, 1993
- Evolution of the complement systemImmunology Today, 1991
- Cloning and nucleotide sequence of cDNA for Ki antigen, a highly conserved nuclear protein detected with sera from patients with systemic lupus erythematosusClinical and Experimental Immunology, 1990