Modification of the skin feeding site by tick saliva mediates virus transmission
- 1 August 1992
- journal article
- Published by Springer Science and Business Media LLC in Cellular and Molecular Life Sciences
- Vol. 48 (8), 779-782
- https://doi.org/10.1007/bf02124302
Abstract
A tick vector of Thogoto (THO) virus was shown to secrete a factor in saliva which potentiates the transmission of THO virus to uninfected ticks feeding on an apparently non-viraemic host. The effect of the saliva activated transmission (SAT) factor on the virus occurred at the site of inoculation in the skin and was apparent even when the virus was introduced 3 days after the SAT factor. The results suggest that tick saliva can play an important role in disease transmission by virtue of host modification at the site of feeding.Keywords
This publication has 17 references indexed in Scilit:
- Sequence Analyses of Thogoto Viral RNA Segment 3: Evidence for a Distant Relationship between an Arbovirus and Members of the OrthomyxoviridaeJournal of General Virology, 1989
- Non-viraemic transmission of Thogoto virus: influence of time and distanceTransactions of the Royal Society of Tropical Medicine and Hygiene, 1989
- Enhancement of Virus Transmission by Tick Salivary GlandsJournal of General Virology, 1989
- Vector capacity of Rhipicephalus appendiculatus and Amblyomma variegatum for Thogoto and Dhori virusesMedical and Veterinary Entomology, 1989
- A Novel Vasodilatory Peptide from the Salivary Glands of the Sand Fly Lutzomyia longipalpisScience, 1989
- Salivary Gland Lysates from the Sand Fly Lutzomyia longipalpis Enhance Leishmania InfectivityScience, 1988
- A Novel Mode of Arbovirus Transmission Involving a Nonviremic HostScience, 1987
- Circuits and Signals of the Skin-Associated Lymphoid Tissues (SALT)Journal of Investigative Dermatology, 1985
- Evidence for multiple receptors mediating fluid secretion in salivary glands of ticksEuropean Journal of Pharmacology, 1983
- Thogoto Virus: a Hitherto Undescribed Agent Isolated from Ticks in KenyaJournal of General Microbiology, 1965