Effect of respiratory gating on reducing lung motion artifacts in PET imaging of lung cancer
- 21 February 2002
- journal article
- nuclear medicine-physics
- Published by Wiley in Medical Physics
- Vol. 29 (3), 366-371
- https://doi.org/10.1118/1.1448824
Abstract
Positron emission tomography (PET) has shown an increase in both sensitivity and specificity over computed tomography (CT) in lung cancer. However, motion artifacts in the fluorodioxydoglucose (FDG) PET images caused by respiration persists to be an important factor in degrading PET image quality and quantification. Motion artifacts lead to two major effects: First, it affects the accuracy of quantitation, producing a reduction of the measured standard uptake value (SUV). Second, the apparent lesion volume is overestimated. Both impact upon the usage of PET images for radiation treatment planning. The first affects the visibility, or contrast, of the lesion. The second results in an increase in the planning target volume, and consequently a greater radiation dose to the normal tissues. One way to compensate for this effect is by applying a multiple‐frame capture technique. The PET data are then acquired in synchronization with the respiratory motion. Reduction in smearing due to gating was investigated in both phantoms and patient studies. Phantom studies showed a dependence of the reduction in smearing on the lesion size, the motion amplitude, and the number of bins used for data acquisition. These studies also showed an improvement in the target‐to‐background ratio, and a more accurate measurement of the SUV. When applied to one patient, respiratory gating showed a 28% reduction in the total lesion volume, and a 56.5% increase in the SUV. This study was conducted as a proof of principle that a gating technique can effectively reduce motion artifacts in PET image acquisition.Keywords
This publication has 11 references indexed in Scilit:
- FDG-PET standardized uptake values in normal anatomical structures using iterative reconstruction segmented attenuation correction and filtered back-projection.European Journal of Nuclear Medicine and Molecular Imaging, 2001
- Respiratory gated irradiation system for heavy-ion radiotherapyInternational Journal of Radiation Oncology*Biology*Physics, 2000
- Use of PET to monitor the response of lung cancer to radiation treatmentEuropean Journal of Nuclear Medicine and Molecular Imaging, 2000
- Breathing‐synchronized radiotherapy program at the University of California Davis Cancer CenterMedical Physics, 2000
- Tumor Treatment Response Based on Visual and Quantitative Changes in Global Tumor Glycolysis Using PET-FDG Imaging The Visual Response Score and the Change in Total Lesion GlycolysisClinical Positron Imaging, 1999
- Non-small cell lung cancer: nodal staging with FDG PET versus CT with correlative lymph node mapping and sampling.Radiology, 1997
- Fluorine-18 deoxyglucose and false-positive results: a major problem in the diagnostics of oncological patientsEuropean Journal of Nuclear Medicine and Molecular Imaging, 1996
- Respiration gated radiotherapy treatment: a technical studyPhysics in Medicine & Biology, 1996
- Persistent or recurrent bronchogenic carcinoma: detection with PET and 2-[F-18]-2-deoxy-D-glucose.Radiology, 1994
- Staging of mediastinal non-small cell lung cancer with FDG PET, CT, and fusion images: preliminary prospective evaluation.Radiology, 1994